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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10288552%21RIV15-MSM-11110___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1097/HJH.0000000000000347
dcterms:description
Blood pressure (BP) response after renal denervation (RDN) is highly variable. Besides baseline BP, no reliable predictors of response have been consistently identified. The differences between patients showing a major BP decrease after RDN vs. nonresponders have not been studied so far. We identified extreme BP responders (first quintile) and nonresponders (fifth quintile) to RDN defined according to office or 24-h ambulatory BP in the European Network COordinating research on Renal Denervation database (n = 109) and compared the baseline characteristics and BP changes 6 months after RDN in both subsets. In extreme responders defined according to ambulatory BP, baseline BP and BP changes 6 months after RDN were similar for office and out-of-the office BP. In contrast, extreme responders defined according to office BP were characterized by a huge white-coat effect at baseline, with dramatic shrinkage at 6 months. Compared with nonresponders, extreme responders defined according to office BP were more frequently women, had higher baseline office - but not ambulatory - BP, and higher estimated glomerular filtration rate (eGFR). In contrast, when considering ambulatory BP decrease to define extreme responders and nonresponders, the single relevant difference between both subsets was baseline ambulatory BP. This study suggests a major overestimation of BP response after RDN in extreme responders defined according to office, but not ambulatory BP. The association of lower eGFR with poor response to RDN is consistent with our previous analysis. The increased proportion of women in extreme responders may reflect sex differences in drug adherence. Blood pressure (BP) response after renal denervation (RDN) is highly variable. Besides baseline BP, no reliable predictors of response have been consistently identified. The differences between patients showing a major BP decrease after RDN vs. nonresponders have not been studied so far. We identified extreme BP responders (first quintile) and nonresponders (fifth quintile) to RDN defined according to office or 24-h ambulatory BP in the European Network COordinating research on Renal Denervation database (n = 109) and compared the baseline characteristics and BP changes 6 months after RDN in both subsets. In extreme responders defined according to ambulatory BP, baseline BP and BP changes 6 months after RDN were similar for office and out-of-the office BP. In contrast, extreme responders defined according to office BP were characterized by a huge white-coat effect at baseline, with dramatic shrinkage at 6 months. Compared with nonresponders, extreme responders defined according to office BP were more frequently women, had higher baseline office - but not ambulatory - BP, and higher estimated glomerular filtration rate (eGFR). In contrast, when considering ambulatory BP decrease to define extreme responders and nonresponders, the single relevant difference between both subsets was baseline ambulatory BP. This study suggests a major overestimation of BP response after RDN in extreme responders defined according to office, but not ambulatory BP. The association of lower eGFR with poor response to RDN is consistent with our previous analysis. The increased proportion of women in extreme responders may reflect sex differences in drug adherence.
dcterms:title
Hyperresponders vs. nonresponder patients after renal denervation: do they differ? Hyperresponders vs. nonresponder patients after renal denervation: do they differ?
skos:prefLabel
Hyperresponders vs. nonresponder patients after renal denervation: do they differ? Hyperresponders vs. nonresponder patients after renal denervation: do they differ?
skos:notation
RIV/00216208:11110/14:10288552!RIV15-MSM-11110___
n3:aktivita
n18:V
n3:aktivity
V
n3:cisloPeriodika
12
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n14:9125035
n3:druhVysledku
n17:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
20154
n3:idVysledku
RIV/00216208:11110/14:10288552
n3:jazykVysledku
n15:eng
n3:klicovaSlova
responders; resistant hypertension; renal denervation; Ambulatory blood pressure
n3:klicoveSlovo
n10:Ambulatory%20blood%20pressure n10:resistant%20hypertension n10:responders n10:renal%20denervation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9149C8DB39A4]
n3:nazevZdroje
Journal of Hypertension
n3:obor
n11:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
32
n3:tvurceVysledku
Sapoval, Marc Volz, Sebastian Azizi, Michel Renkin, Jean Persu, Alexandre Elvan, Arif Staessen, Jan A. Pechere-Bertschi, Antoinette Jin, Yu Rosa, Ján Kahan, Thomas Kjeldsen, Sverre Mark, Patrick B. Burnier, Michel Elmula, Fadl Elmula M. Fadl
n3:wos
000345019800020
s:issn
0263-6352
s:numberOfPages
6
n8:doi
10.1097/HJH.0000000000000347
n16:organizacniJednotka
11110