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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10286780%21RIV15-MSM-11110___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.ijantimicag.2014.05.011
dcterms:description
In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics. Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion may increase the time for which its plasma concentration exceeds the minimum inhibitory concentrations (MICs) of suspected pathogens. The objectives of this study were to compare the pharmacokinetic parameters of imipenem administered by standard short infusion (1 g imipenem/1 g cilastatin over 30 min three times daily) and by extended infusion with a reduced total dose (0.5 g imipenem/0.5 g cilastatin over 3 h four times daily) and to compare the target pharmacokinetic/pharmacodynamic indices, namely percentage of the dosing interval for which the free plasma concentration of imipenem exceeds the MIC and 4x MIC (%fT(>MIC) and %fT(>4xMIC)) of 0.5, 1, 2 and 4 mg/L, for these two regimens in critically ill adult patients with nosocomial pneumonia on Day 2 of empirical antibiotic therapy. The study included 22 patients. Whilst no significant differences were found between both groups for %fT(>MIC), %fT(>4xMIC) was 87.4 +/- 12.19%, 68.6 +/- 15.08%, 47.31 +/- 6.64% and 27.81 +/- 9.52% of the 8-h interval in the short infusion group for MICs of 0.5, 1, 2 and 4 mg/L, respectively, and 85.15 +/- 17.57%, 53.14 +/- 27.27%, 13.55 +/- 24.47% and 0 +/- 0% of the 6-h interval for the extended infusion group. In conclusion, administration of 0.5 g of imipenem by a 3-h infusion every 6 h does not provide sufficient drug concentrations to treat infections caused by pathogens with a MIC of }= 2 mg/L. In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics. Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion may increase the time for which its plasma concentration exceeds the minimum inhibitory concentrations (MICs) of suspected pathogens. The objectives of this study were to compare the pharmacokinetic parameters of imipenem administered by standard short infusion (1 g imipenem/1 g cilastatin over 30 min three times daily) and by extended infusion with a reduced total dose (0.5 g imipenem/0.5 g cilastatin over 3 h four times daily) and to compare the target pharmacokinetic/pharmacodynamic indices, namely percentage of the dosing interval for which the free plasma concentration of imipenem exceeds the MIC and 4x MIC (%fT(>MIC) and %fT(>4xMIC)) of 0.5, 1, 2 and 4 mg/L, for these two regimens in critically ill adult patients with nosocomial pneumonia on Day 2 of empirical antibiotic therapy. The study included 22 patients. Whilst no significant differences were found between both groups for %fT(>MIC), %fT(>4xMIC) was 87.4 +/- 12.19%, 68.6 +/- 15.08%, 47.31 +/- 6.64% and 27.81 +/- 9.52% of the 8-h interval in the short infusion group for MICs of 0.5, 1, 2 and 4 mg/L, respectively, and 85.15 +/- 17.57%, 53.14 +/- 27.27%, 13.55 +/- 24.47% and 0 +/- 0% of the 6-h interval for the extended infusion group. In conclusion, administration of 0.5 g of imipenem by a 3-h infusion every 6 h does not provide sufficient drug concentrations to treat infections caused by pathogens with a MIC of }= 2 mg/L.
dcterms:title
Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions
skos:prefLabel
Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions
skos:notation
RIV/00216208:11110/14:10286780!RIV15-MSM-11110___
n4:aktivita
n18:S n18:I
n4:aktivity
I, S
n4:cisloPeriodika
4
n4:dodaniDat
n7:2015
n4:domaciTvurceVysledku
n13:2143534 n13:8625123
n4:druhVysledku
n16:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
36380
n4:idVysledku
RIV/00216208:11110/14:10286780
n4:jazykVysledku
n10:eng
n4:klicovaSlova
PK/PD; Prolonged infusion; Pneumonia; ICU; Imipenem
n4:klicoveSlovo
n11:PK%2FPD n11:Pneumonia n11:Prolonged%20infusion n11:Imipenem n11:ICU
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[B38489EBDEB1]
n4:nazevZdroje
International Journal of Antimicrobial Agents
n4:obor
n5:FP
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n7:2014
n4:svazekPeriodika
44
n4:tvurceVysledku
Siller, Michal Balík, Martin Suchankova, Hana Urbánek, Karel Lipš, Michal Strojil, Jan
n4:wos
000343109600014
s:issn
0924-8579
s:numberOfPages
5
n17:doi
10.1016/j.ijantimicag.2014.05.011
n8:organizacniJednotka
11110