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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10285644%21RIV15-MSM-11110___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1093/aje/kwt273
dcterms:description
The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially nonlinear in intensity of exposure to 15 case-control studies of cigarette smoking and lung cancer (19852009). Our model accommodated modification of the excess odds ratio per pack-year of cigarette smoking by time since smoking cessation among former smokers. We observed negative effect modification of the association of pack-years of cigarette smoking and lung cancer by intensity of cigarette smoke for persons who smoked more than 2030 cigarettes per day. Patterns of effect modification were similar across individual studies and across major lung cancer subtypes. We observed strong negative effect modification by time since smoking cessation. Application of our method in this example of cigarette smoking and lung cancer demonstrated that reducing a complex exposure history to a metric such as cumulative exposure is too restrictive. The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially nonlinear in intensity of exposure to 15 case-control studies of cigarette smoking and lung cancer (19852009). Our model accommodated modification of the excess odds ratio per pack-year of cigarette smoking by time since smoking cessation among former smokers. We observed negative effect modification of the association of pack-years of cigarette smoking and lung cancer by intensity of cigarette smoke for persons who smoked more than 2030 cigarettes per day. Patterns of effect modification were similar across individual studies and across major lung cancer subtypes. We observed strong negative effect modification by time since smoking cessation. Application of our method in this example of cigarette smoking and lung cancer demonstrated that reducing a complex exposure history to a metric such as cumulative exposure is too restrictive.
dcterms:title
Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study
skos:prefLabel
Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study
skos:notation
RIV/00216208:11110/14:10285644!RIV15-MSM-11110___
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n18:4898362
n3:druhVysledku
n12:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
13082
n3:idVysledku
RIV/00216208:11110/14:10285644
n3:jazykVysledku
n6:eng
n3:klicovaSlova
pooled analysis; lung cancer; effect modification; cumulative exposure; cigarette smoke
n3:klicoveSlovo
n5:cigarette%20smoke n5:effect%20modification n5:lung%20cancer n5:pooled%20analysis n5:cumulative%20exposure
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[36D114BFA574]
n3:nazevZdroje
American Journal of Epidemiology
n3:obor
n17:FN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
45
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
179
n3:tvurceVysledku
Consonni, Dario Vlaanderen, Jelle Caporaso, Neil Szeszenia-Dabrowska, Neonila Janout, Vladimír Gustavsson, Per McLaughlin, John Mannetje, Andrea ' t Pearce, Neil Portengen, Lutzen Landi, Maria Teresa Wichmann, Heinz-Erich Olsson, Ann Stuecker, Isabelle Siemiatycki, Jack Demers, Paul Joeckel, Karl-Heinz Rudnai, Peter Brueske, Irene Foretová, Lenka Bencko, Vladimír Kendzia, Benjamin Mirabelli, Dario Ahrens, Wolfgang Zaridze, David Boffetta, Paolo Tardon, Adonina Richiardi, Lorenzo Guida, Florence Pohlabeln, Hermann Merletti, Franco Schuez, Joachim Fabianova, Eleonora Field, John K. Plato, Nils Lissowska, Jolanta Pesch, Beate
n3:wos
000330190600003
s:issn
0002-9262
s:numberOfPages
9
n10:doi
10.1093/aje/kwt273
n16:organizacniJednotka
11110