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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10285576%21RIV15-MSM-11110___
rdf:type
skos:Concept n20:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3109/02688697.2013.872229
dcterms:description
The recognition of anaplastic foci within low-grade gliomas is of extreme importance in patients under follow-up for Grade II gliomas. We present the algorithm of MR spectroscopy (MRS)-guided brain biopsy and its correlation with tumour histology. Methods. Twenty-seven patients harbouring suspected Grade II/III glioma were examined on our 3T MR. 2D PRESS-CSI metabolite images of Choline/Creatine, Creatine/N-acetylaspartate and Choline/N-acetylaspartate were calculated and exported to the DICOM format. According to these maps, a stereobiopsy was performed at the point of maximum Choline/Creatine ratio prior to tumour resection. In the case of enhancing tumour, a subsequent biopsy was performed from the point of enhancement. Comparisons were made between the histology of the biopsied specimens and the resected tumours. Results. Eleven tumours were diagnosed as high-grade and sixteen as low-grade lesions. The correlation between main spectroscopic ratios (Cho/Cr and Cho/NAA) was strongly positive at the points of maximum Cho/Cr. Similar results were obtained at the points of contrast enhancement. Comparison of histological parameters of biopsy samples at the points of maximum Cho/Cr and histological examination of the completely resected tumours gives a strong correlation of tumour grade, number of mitoses and Ki-67 expression. The diagnostic accuracy of MRS-guided biopsy was 84%. The absolute value of Cho/NAA was higher in high-grade compared to that of low-grade lesions. The value of Cho/NAA ratio of 0.9 using MRS produced a sensitivity and specificity of 78% in the differentiation between low-grade and high-grade lesions. Combining MRS with structural MR, the sensitivity increased to 86% and the specificity to 80%. Conclusions. Strong correlation was demonstrated between Cho/Cr and Ch/NAA ratios. ches The recognition of anaplastic foci within low-grade gliomas is of extreme importance in patients under follow-up for Grade II gliomas. We present the algorithm of MR spectroscopy (MRS)-guided brain biopsy and its correlation with tumour histology. Methods. Twenty-seven patients harbouring suspected Grade II/III glioma were examined on our 3T MR. 2D PRESS-CSI metabolite images of Choline/Creatine, Creatine/N-acetylaspartate and Choline/N-acetylaspartate were calculated and exported to the DICOM format. According to these maps, a stereobiopsy was performed at the point of maximum Choline/Creatine ratio prior to tumour resection. In the case of enhancing tumour, a subsequent biopsy was performed from the point of enhancement. Comparisons were made between the histology of the biopsied specimens and the resected tumours. Results. Eleven tumours were diagnosed as high-grade and sixteen as low-grade lesions. The correlation between main spectroscopic ratios (Cho/Cr and Cho/NAA) was strongly positive at the points of maximum Cho/Cr. Similar results were obtained at the points of contrast enhancement. Comparison of histological parameters of biopsy samples at the points of maximum Cho/Cr and histological examination of the completely resected tumours gives a strong correlation of tumour grade, number of mitoses and Ki-67 expression. The diagnostic accuracy of MRS-guided biopsy was 84%. The absolute value of Cho/NAA was higher in high-grade compared to that of low-grade lesions. The value of Cho/NAA ratio of 0.9 using MRS produced a sensitivity and specificity of 78% in the differentiation between low-grade and high-grade lesions. Combining MRS with structural MR, the sensitivity increased to 86% and the specificity to 80%. Conclusions. Strong correlation was demonstrated between Cho/Cr and Ch/NAA ratios. ches
dcterms:title
Recognition of anaplastic foci within low-grade gliomas using MR spectroscopy Recognition of anaplastic foci within low-grade gliomas using MR spectroscopy
skos:prefLabel
Recognition of anaplastic foci within low-grade gliomas using MR spectroscopy Recognition of anaplastic foci within low-grade gliomas using MR spectroscopy
skos:notation
RIV/00216208:11110/14:10285576!RIV15-MSM-11110___
n4:aktivita
n11:P n11:V
n4:aktivity
P(GPP304/10/P464), V
n4:cisloPeriodika
5
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n8:8725705 n8:1692267 n8:4485483 n8:2500027 n8:8591644
n4:druhVysledku
n12:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
41600
n4:idVysledku
RIV/00216208:11110/14:10285576
n4:jazykVysledku
n5:eng
n4:klicovaSlova
stereotactic biopsy; MR spectroscopy; MR imaging; low-grade glioma; brain tumour; anaplastic focus
n4:klicoveSlovo
n9:low-grade%20glioma n9:MR%20imaging n9:brain%20tumour n9:anaplastic%20focus n9:stereotactic%20biopsy n9:MR%20spectroscopy
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[F5A7D1C8843F]
n4:nazevZdroje
British Journal of Neurosurgery
n4:obor
n14:FH
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
9
n4:projekt
n19:GPP304%2F10%2FP464
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
28
n4:tvurceVysledku
Beneš, Vladimír de Lacy, Patricia Netuka, David Vrána, Jiří Hrabal, Petr Kramář, Filip Bradáč, Ondřej Jírů, Filip Hořínek, Daniel
n4:wos
000341753500010
s:issn
0268-8697
s:numberOfPages
6
n3:doi
10.3109/02688697.2013.872229
n18:organizacniJednotka
11110