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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10285206%21RIV15-MSM-11110___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1371/journal.pone.0111696
dcterms:description
Radix lagotis is an intermediate snail host of the nasal bird schistosome Trichobilharzia regenti. Changes in defence responses in infected snails that might be related to host-parasite compatibility are not known. This study therefore aimed to characterize R. lagotis haemocyte defence mechanisms and determine the extent to which they are modulated by T. regenti. Histological observations of R. lagotis infected with T. regenti revealed that early phases of infection were accompanied by haemocyte accumulation around the developing larvae 2-36 h post exposure (p. e.) to the parasite. At later time points, 44-92 h p. e., no haemocytes were observed around T. regenti. Additionally, microtubular aggregates likely corresponding to phagocytosed ciliary plates of T. regenti miracidia were observed within haemocytes by use of transmission electron microscopy. When the infection was in the patent phase, haemocyte phagocytic activity and hydrogen peroxide production were significantly reduced in infected R. lagotis when compared to uninfected counterparts, whereas haemocyte abundance increased in infected snails. At a molecular level, protein kinase C (PKC) and extracellular-signal regulated kinase (ERK) were found to play an important role in regulating these defence reactions in R. lagotis. Moreover, haemocytes from snails with patent infection displayed lower PKC and ERK activity in cell adhesion assays when compared to those from uninfected snails, which may therefore be related to the reduced defence activities of these cells. These data provide the first integrated insight into the immunobiology of R. lagotis and demonstrate modulation of haemocyte-mediated responses in patent T. regenti infected snails. Given that immunomodulation occurs during patency, interference of snail-host defence by T. regenti might be important for the sustained production and/or release of infective cercariae. Radix lagotis is an intermediate snail host of the nasal bird schistosome Trichobilharzia regenti. Changes in defence responses in infected snails that might be related to host-parasite compatibility are not known. This study therefore aimed to characterize R. lagotis haemocyte defence mechanisms and determine the extent to which they are modulated by T. regenti. Histological observations of R. lagotis infected with T. regenti revealed that early phases of infection were accompanied by haemocyte accumulation around the developing larvae 2-36 h post exposure (p. e.) to the parasite. At later time points, 44-92 h p. e., no haemocytes were observed around T. regenti. Additionally, microtubular aggregates likely corresponding to phagocytosed ciliary plates of T. regenti miracidia were observed within haemocytes by use of transmission electron microscopy. When the infection was in the patent phase, haemocyte phagocytic activity and hydrogen peroxide production were significantly reduced in infected R. lagotis when compared to uninfected counterparts, whereas haemocyte abundance increased in infected snails. At a molecular level, protein kinase C (PKC) and extracellular-signal regulated kinase (ERK) were found to play an important role in regulating these defence reactions in R. lagotis. Moreover, haemocytes from snails with patent infection displayed lower PKC and ERK activity in cell adhesion assays when compared to those from uninfected snails, which may therefore be related to the reduced defence activities of these cells. These data provide the first integrated insight into the immunobiology of R. lagotis and demonstrate modulation of haemocyte-mediated responses in patent T. regenti infected snails. Given that immunomodulation occurs during patency, interference of snail-host defence by T. regenti might be important for the sustained production and/or release of infective cercariae.
dcterms:title
Influence of Trichobilharzia regenti (Digenea: Schistosomatidae) on the Defence Activity of Radix lagotis (Lymnaeidae) Haemocytes Influence of Trichobilharzia regenti (Digenea: Schistosomatidae) on the Defence Activity of Radix lagotis (Lymnaeidae) Haemocytes
skos:prefLabel
Influence of Trichobilharzia regenti (Digenea: Schistosomatidae) on the Defence Activity of Radix lagotis (Lymnaeidae) Haemocytes Influence of Trichobilharzia regenti (Digenea: Schistosomatidae) on the Defence Activity of Radix lagotis (Lymnaeidae) Haemocytes
skos:notation
RIV/00216208:11110/14:10285206!RIV15-MSM-11110___
n3:aktivita
n13:I n13:S
n3:aktivity
I, S
n3:cisloPeriodika
11
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n17:9391835
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
21712
n3:idVysledku
RIV/00216208:11110/14:10285206
n3:jazykVysledku
n19:eng
n3:klicovaSlova
mansoni; in-vitro; snail hosts; immune-responses; avian schistosome; electron-microscopy; protein-kinase; stagnalis hemocytes; echinostoma-paraensei; resistant biomphalaria-glabrata
n3:klicoveSlovo
n4:immune-responses n4:mansoni n4:protein-kinase n4:stagnalis%20hemocytes n4:electron-microscopy n4:avian%20schistosome n4:echinostoma-paraensei n4:resistant%20biomphalaria-glabrata n4:snail%20hosts n4:in-vitro
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[279AACC17F16]
n3:nazevZdroje
PLoS ONE
n3:obor
n8:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
9
n3:tvurceVysledku
Vostrý, Martin Skála, Vladimír Jindrová, Zuzana Černíková, Alena Horák, Petr Kašný, Martin Walker, Anthony J.
n3:wos
000344556900065
s:issn
1932-6203
s:numberOfPages
11
n14:doi
10.1371/journal.pone.0111696
n11:organizacniJednotka
11110