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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10284171%21RIV15-MSM-11110___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.leukres.2014.01.012
dcterms:description
MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months). MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).
dcterms:title
Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
skos:prefLabel
Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
skos:notation
RIV/00216208:11110/14:10284171!RIV15-MSM-11110___
n4:aktivita
n8:I n8:P
n4:aktivity
I, P(GBP302/12/G157)
n4:cisloPeriodika
5
n4:dodaniDat
n15:2015
n4:domaciTvurceVysledku
n5:8157332 n5:9688064 n5:6190898 n5:9174974 n5:2378833 n5:7931360 n5:1129244 n5:3750868 n5:8214824 n5:6581609
n4:druhVysledku
n11:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
22810
n4:idVysledku
RIV/00216208:11110/14:10284171
n4:jazykVysledku
n19:eng
n4:klicovaSlova
Chromothripsis; Deletion 5q; Genome instability; Complex chromosomal aberrations; Myelodysplastic syndromes
n4:klicoveSlovo
n7:Deletion%205q n7:Complex%20chromosomal%20aberrations n7:Myelodysplastic%20syndromes n7:Chromothripsis n7:Genome%20instability
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[7B9CC121836F]
n4:nazevZdroje
Leukemia Research
n4:obor
n13:FD
n4:pocetDomacichTvurcuVysledku
10
n4:pocetTvurcuVysledku
18
n4:projekt
n12:GBP302%2F12%2FG157
n4:rokUplatneniVysledku
n15:2014
n4:svazekPeriodika
38
n4:tvurceVysledku
Buryová, Halka Bystricka, Dagmar Lizcová, Libuše Neuwirtová, Radana Izáková, Silvia Čermák, Jaroslav Dohnalová, Alena Šišková, Magda Krejčík, Zdeněk Ransdorfová, Šárka Kostýlková, Karla Merkerova Dostalova, Michaela Nováková, Milena Šárová, Iveta Michalová, Kyra Zemanová, Zuzana Jonášová, Anna Brezinova, Jana
n4:wos
000334763300004
s:issn
0145-2126
s:numberOfPages
8
n20:doi
10.1016/j.leukres.2014.01.012
n9:organizacniJednotka
11110