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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10284099%21RIV15-MSM-11110___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.5301/ijao.5000291
dcterms:description
Background: The aim of our study was to analyze, in a pig model of prolonged ventricular fibrillation (VF) treated by veno-arterial extracorporeal membrane oxygenation (ECMO), the time dependent changes of VF wavelet frequency obtained from intracardial signals and its relations to return of spontaneous circulation (ROSC). Methods: 11 female pigs (50.3 +/- 3.4 kg) under general anesthesia had undergone 15 min of VF with ECMO flow of 5 to 10 ml/kg per min simulating %22untreated%22 VF followed by continued VF with full ECMO flow of 100 ml/kg per min. The median frequency (MF) of VF from right ventricular apex, coronary perfusion pressure, myocardial oxygen metabolism and resuscitability were determined. Results: Median (interquartile range) of MF of fibrillatory wavelets in minute 15 of low ECMO flow [9.7 Hz (8.3; 10.1)] was not significantly changed in comparison to minute 1 [10.5 Hz (9.8; 12.4)], p = 0.12. Five minutes after full ECMO initiation MF increased [11.6 Hz (10.6; 13.5)], p = 0.04 (compared to minute 15 of VF) and did not deteriorate during the rest of ECMO treatment. Out of all subjects, three animals did not reach ROSC. Those subjects demonstrated deeper decrease of MF at the VF minute 15 as compared to others [-2.4 Hz (-2.5; -2.3) vs. -0.6 Hz (-1.6; -0.1)] and continuously significantly higher increase in MF on full ECMO support [4.3 Hz (2.9; 5.6) vs. 1.1 Hz (0.6; 1.6)] with p = 0.05 for both observations, respectively. Conclusions: The veno-arterial ECMO reperfusion influences MF of VF wavelet obtained from right ventricular apex. The course of changes in wavelet frequency corresponds to a presence of later ROSC. Background: The aim of our study was to analyze, in a pig model of prolonged ventricular fibrillation (VF) treated by veno-arterial extracorporeal membrane oxygenation (ECMO), the time dependent changes of VF wavelet frequency obtained from intracardial signals and its relations to return of spontaneous circulation (ROSC). Methods: 11 female pigs (50.3 +/- 3.4 kg) under general anesthesia had undergone 15 min of VF with ECMO flow of 5 to 10 ml/kg per min simulating %22untreated%22 VF followed by continued VF with full ECMO flow of 100 ml/kg per min. The median frequency (MF) of VF from right ventricular apex, coronary perfusion pressure, myocardial oxygen metabolism and resuscitability were determined. Results: Median (interquartile range) of MF of fibrillatory wavelets in minute 15 of low ECMO flow [9.7 Hz (8.3; 10.1)] was not significantly changed in comparison to minute 1 [10.5 Hz (9.8; 12.4)], p = 0.12. Five minutes after full ECMO initiation MF increased [11.6 Hz (10.6; 13.5)], p = 0.04 (compared to minute 15 of VF) and did not deteriorate during the rest of ECMO treatment. Out of all subjects, three animals did not reach ROSC. Those subjects demonstrated deeper decrease of MF at the VF minute 15 as compared to others [-2.4 Hz (-2.5; -2.3) vs. -0.6 Hz (-1.6; -0.1)] and continuously significantly higher increase in MF on full ECMO support [4.3 Hz (2.9; 5.6) vs. 1.1 Hz (0.6; 1.6)] with p = 0.05 for both observations, respectively. Conclusions: The veno-arterial ECMO reperfusion influences MF of VF wavelet obtained from right ventricular apex. The course of changes in wavelet frequency corresponds to a presence of later ROSC.
dcterms:title
Median frequencies of prolonged ventricular fibrillation treated by V-A ECMO correspond to a return of spontaneous circulation rate Median frequencies of prolonged ventricular fibrillation treated by V-A ECMO correspond to a return of spontaneous circulation rate
skos:prefLabel
Median frequencies of prolonged ventricular fibrillation treated by V-A ECMO correspond to a return of spontaneous circulation rate Median frequencies of prolonged ventricular fibrillation treated by V-A ECMO correspond to a return of spontaneous circulation rate
skos:notation
RIV/00216208:11110/14:10284099!RIV15-MSM-11110___
n4:aktivita
n16:I
n4:aktivity
I
n4:cisloPeriodika
1
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n13:4803515 n13:8149690 n13:4894596 n13:7501064 n13:7506449 n13:5023831 n13:1809210
n4:druhVysledku
n18:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
28199
n4:idVysledku
RIV/00216208:11110/14:10284099
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Cardiopulmonary resuscitation; Animal model; Veno-arterial ECMO; Ventricular fibrillation
n4:klicoveSlovo
n15:Veno-arterial%20ECMO n15:Animal%20model n15:Ventricular%20fibrillation n15:Cardiopulmonary%20resuscitation
n4:kodStatuVydavatele
IT - Italská republika
n4:kontrolniKodProRIV
[D347DC1F5F74]
n4:nazevZdroje
International Journal of Artificial Organs
n4:obor
n10:FA
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
10
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
37
n4:tvurceVysledku
Boucek, Tomas Mlček, Mikuláš Huptych, Michal Bělohlávek, Jan Fichtl, Jaromír Svoboda, Tomáš Hrachovina, Matěj Kittnar, Otomar Havránek, Štěpán Linhart, Aleš
n4:wos
000338513800006
s:issn
0391-3988
s:numberOfPages
10
n19:doi
10.5301/ijao.5000291
n5:organizacniJednotka
11110