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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10284098%21RIV15-MSM-11110___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.3109/00365513.2013.860617
dcterms:description
The aim of the study was to verify differences between reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4), as well as the cut-off for anti-thyroid peroxidase antibodies (TPO Ab) in pregnant women. Additionally, to compare these reference intervals with those recommended by the manufacturers for a healthy population. Levels of TSH, FT4, and TPO Ab were determined in a group of pregnant women (n = 216) with no history of thyroid dysfunction. Simultaneously, reference intervals for thyroid function tests were established with 7 different analytical systems representing those immunoassays most often used globally. The reference intervals for FT4 were slightly different, according to the system used by each manufacturer. Those for Architect, Centaur, Modular E170, and RIA Immunotech were slightly higher than those for Immulite 2500 and AIA 2000; the lowest being for UniCel DxI (8.13-13.2 pmol/L). For TSH, a higher interval (0.25-3.86 mU/L) is recommended for Modular E170 and IRMA Immunotech; and a lower one (0.17-2.81 mU/L) for Immulite 2500 and AIA 2000. The established cut-off limits for TPO-Ab differ according to the system used and are similar to those recommended by their manufacturers. The aim of the study was to verify differences between reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4), as well as the cut-off for anti-thyroid peroxidase antibodies (TPO Ab) in pregnant women. Additionally, to compare these reference intervals with those recommended by the manufacturers for a healthy population. Levels of TSH, FT4, and TPO Ab were determined in a group of pregnant women (n = 216) with no history of thyroid dysfunction. Simultaneously, reference intervals for thyroid function tests were established with 7 different analytical systems representing those immunoassays most often used globally. The reference intervals for FT4 were slightly different, according to the system used by each manufacturer. Those for Architect, Centaur, Modular E170, and RIA Immunotech were slightly higher than those for Immulite 2500 and AIA 2000; the lowest being for UniCel DxI (8.13-13.2 pmol/L). For TSH, a higher interval (0.25-3.86 mU/L) is recommended for Modular E170 and IRMA Immunotech; and a lower one (0.17-2.81 mU/L) for Immulite 2500 and AIA 2000. The established cut-off limits for TPO-Ab differ according to the system used and are similar to those recommended by their manufacturers.
dcterms:title
Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems
skos:prefLabel
Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems
skos:notation
RIV/00216208:11110/14:10284098!RIV15-MSM-11110___
n5:aktivita
n19:I
n5:aktivity
I
n5:cisloPeriodika
2
n5:dodaniDat
n17:2015
n5:domaciTvurceVysledku
n14:9358668 n14:8705097
n5:druhVysledku
n7:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
41744
n5:idVysledku
RIV/00216208:11110/14:10284098
n5:jazykVysledku
n11:eng
n5:klicovaSlova
thyroid-stimulating hormone; reference interval; pregnancy; immunoassay; Thyroxine
n5:klicoveSlovo
n6:immunoassay n6:thyroid-stimulating%20hormone n6:reference%20interval n6:pregnancy n6:Thyroxine
n5:kodStatuVydavatele
NO - Norské království
n5:kontrolniKodProRIV
[72B5C7951E8A]
n5:nazevZdroje
Scandinavian Journal of Clinical and Laboratory Investigation
n5:obor
n15:CE
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
3
n5:rokUplatneniVysledku
n17:2014
n5:svazekPeriodika
74
n5:tvurceVysledku
Zima, Tomáš Bartos, Vladimir Springer, Drahomíra
n5:wos
000334737700003
s:issn
0036-5513
s:numberOfPages
7
n9:doi
10.3109/00365513.2013.860617
n12:organizacniJednotka
11110