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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10282565%21RIV15-MSM-11110___
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1038/ki.2014.63
dcterms:description
The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole spectrum of IgAN. Over a median follow-up of 4.7 years, 86% received renin-angiotensin system blockade and 42% glucocorticoid/immunosuppressive drugs. M, S. and T lesions independently predicted the loss of estimated glomerular filtration rate (eGFR) and a lower renal survival. Their value was also assessed in patients not represented in the Oxford cohort. In individuals with eGFR less than 30 ml/min per 1.73 m(2), the M and T lesions independently predicted a poor survival. In those with proteinuria under 0.5 g/day, both M and E lesions were associated with a rise in proteinuria to 1 or 2 g/day or more. The addition of M, S, and T lesions to clinical variables significantly enhanced the ability to predict progression only in those who did not receive immunosuppression (net reclassification index 11.5%). The VALIGA study provides a validation of the Oxford classification in a large European cohort of IgAN patients across the whole spectrum of the disease. The predictive value of pathology MEST score is reduced by glucocorticoid/immunosuppressive therapy. The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole spectrum of IgAN. Over a median follow-up of 4.7 years, 86% received renin-angiotensin system blockade and 42% glucocorticoid/immunosuppressive drugs. M, S. and T lesions independently predicted the loss of estimated glomerular filtration rate (eGFR) and a lower renal survival. Their value was also assessed in patients not represented in the Oxford cohort. In individuals with eGFR less than 30 ml/min per 1.73 m(2), the M and T lesions independently predicted a poor survival. In those with proteinuria under 0.5 g/day, both M and E lesions were associated with a rise in proteinuria to 1 or 2 g/day or more. The addition of M, S, and T lesions to clinical variables significantly enhanced the ability to predict progression only in those who did not receive immunosuppression (net reclassification index 11.5%). The VALIGA study provides a validation of the Oxford classification in a large European cohort of IgAN patients across the whole spectrum of the disease. The predictive value of pathology MEST score is reduced by glucocorticoid/immunosuppressive therapy.
dcterms:title
Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments
skos:prefLabel
Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments
skos:notation
RIV/00216208:11110/14:10282565!RIV15-MSM-11110___
n3:aktivita
n19:V
n3:aktivity
V
n3:cisloPeriodika
4
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n15:5909627
n3:druhVysledku
n11:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
52915
n3:idVysledku
RIV/00216208:11110/14:10282565
n3:jazykVysledku
n18:eng
n3:klicovaSlova
risk factors; renal pathology; proteinuria; progression of chronic renal failure; IgA nephropathy; glomerular diseases
n3:klicoveSlovo
n5:risk%20factors n5:progression%20of%20chronic%20renal%20failure n5:glomerular%20diseases n5:renal%20pathology n5:IgA%20nephropathy n5:proteinuria
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[DF7F045934F5]
n3:nazevZdroje
Kidney International
n3:obor
n12:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
33
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
86
n3:tvurceVysledku
Feriozzi, Sandro Segoloni, Giuseppe Gesualdo, Loreto Ferrario, Franco Lunberg, Sigrid Coppo, Rosanna Giannakakis, Costantinos Barratt, Jonathan Honsova, Eva Cook, H. Terence Asunis, Anna Maria Mazzucco, Gianna Praga, Manuel Gutierrez, Eduardo Di Palma, Anna Maria Pani, Antonello Feehally, John Durlik, Magalena Sundelin, B. Brigitta Camilla, Roberta Perkowska-Ptasinska, Agnieszka Cattran, Daniel Morando, Laura Tesař, Vladimír Rollino, Cristiana Tardanico, Regina Bellur, Shubha Roberts, Ian S. D. Troyanov, Stephan Emma, Francesco Moggia, Elisabetta Cancarini, Giovanni Amore, Alessandro
n3:wos
000342881000022
s:issn
0085-2538
s:numberOfPages
9
n4:doi
10.1038/ki.2014.63
n8:organizacniJednotka
11110