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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10272441%21RIV15-MSM-11110___
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.biomaterials.2014.04.067
dcterms:description
Carbon nanotubes (CNT) are one of the most promising nanomaterials for use in medicine. The blood biocompatibility of CNT is a critical safety issue. In the bloodstream, proteins bind to CNT through non-covalent interactions to form a protein corona, thereby largely defining the biological properties of the CNT. Here, we characterize the interactions of carboxylated-multiwalled carbon nanotubes (CNTCOOH) with common human proteins and investigate the effect of the different protein coronas on the interaction of CNTCOOH with human blood platelets (PLT). Molecular modeling and different photophysical techniques were employed to characterize the binding of albumin (HSA), fibrinogen (FBG), gamma-globulins (IgG) and histone H1 (H1) on CNTCOOH. We found that the identity of protein forming the corona greatly affects the outcome of CNTCOOH's interaction with blood PLT. Bare CNTCOOH-induced PLT aggregation and the release of platelet membrane microparticles (PMP). HSA corona attenuated the PLT aggregating activity of CNTCOOH, while FBG caused the agglomeration of CNTCOOH nanomaterial, thereby diminishing the effect of CNTCOOH on PLT. In contrast, the IgG corona caused PLT fragmentation, and the NI corona induced a strong PLT aggregation, thus potentiating the release of PMP. Published by Elsevier Ltd. Carbon nanotubes (CNT) are one of the most promising nanomaterials for use in medicine. The blood biocompatibility of CNT is a critical safety issue. In the bloodstream, proteins bind to CNT through non-covalent interactions to form a protein corona, thereby largely defining the biological properties of the CNT. Here, we characterize the interactions of carboxylated-multiwalled carbon nanotubes (CNTCOOH) with common human proteins and investigate the effect of the different protein coronas on the interaction of CNTCOOH with human blood platelets (PLT). Molecular modeling and different photophysical techniques were employed to characterize the binding of albumin (HSA), fibrinogen (FBG), gamma-globulins (IgG) and histone H1 (H1) on CNTCOOH. We found that the identity of protein forming the corona greatly affects the outcome of CNTCOOH's interaction with blood PLT. Bare CNTCOOH-induced PLT aggregation and the release of platelet membrane microparticles (PMP). HSA corona attenuated the PLT aggregating activity of CNTCOOH, while FBG caused the agglomeration of CNTCOOH nanomaterial, thereby diminishing the effect of CNTCOOH on PLT. In contrast, the IgG corona caused PLT fragmentation, and the NI corona induced a strong PLT aggregation, thus potentiating the release of PMP. Published by Elsevier Ltd.
dcterms:title
The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets
skos:prefLabel
The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets
skos:notation
RIV/00216208:11110/14:10272441!RIV15-MSM-11110___
n3:aktivita
n4:I n4:P
n3:aktivity
I, P(LH12014)
n3:cisloPeriodika
24
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n14:8564078
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
13469
n3:idVysledku
RIV/00216208:11110/14:10272441
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Protein corona; Nanotoxicity; Biocompatibility; Platelets; Nanoparticles; Carbon nanotubes
n3:klicoveSlovo
n8:Nanotoxicity n8:Platelets n8:Nanoparticles n8:Carbon%20nanotubes n8:Protein%20corona n8:Biocompatibility
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[A7A7E8A3EACD]
n3:nazevZdroje
Biomaterials
n3:obor
n18:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n9:LH12014
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Diduch, Lukas L. Karnaukhova, Elena De Paoli, Silvia H. Bonevich, John E. Tegegn, Tseday Z. Strader, Michael B. Holada, Karel Orecna, Martina Simak, Jan
n3:wos
000338804500005
s:issn
0142-9612
s:numberOfPages
13
n13:doi
10.1016/j.biomaterials.2014.04.067
n5:organizacniJednotka
11110