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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10272303%21RIV15-MSM-11110___
rdf:type
skos:Concept n20:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.jsbmb.2014.06.007
dcterms:description
Objectives To investigate the mechanisms mediating the adverse effects of cholesterol in CIS and to determine the role of the nexus between the vitamin D3 (D3) and cholesterol pathways. Design Multi-center, prospective, longitudinal prospective study. Setting University hospital multiple sclerosis centers. Intervention Serum samples were obtained prior to any treatment from study subjects. Methods Serum obtained prior to any treatment from 172 CIS patients enrolled in a multi-center, prospective, longitudinal study (119 females: 53 males, age: 28.1 +- SD 8.1 years) were analyzed for high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (ApoAI), ApoAII, ApoB, ApoE, and lipoprotein-a. Levels of 25-hydroxy vitamin D3 (25(OH)D3), 1,25-dihydroxy D3, and 24,25-dihydroxy D3 were measured using liquid chromatography-mass spectrometry. Results Greater levels of HDL-C biomarkers (e.g., HDL-C itself, ApoAI, ApoAII and paroxonase arylesterase activity) and LDL-C biomarkers (e.g., LDL-C itself, Apo B) were associated with greater 25(OH)D3. The effects of HDL-C biomarkers were stronger than those of LDL-C. Free cholesterol and cholesteryl ester levels were positively associated with higher 25(OH)D3 levels. Cholesterol palmitate was particularly potent. The nexus between the D3 and cholesterol pathways was proximal to, or in linkage disequilibrium with, 7-dehydrocholesterol reductase DHCR7 rs1790349, endothelial lipase LIPG rs4939883 and proprotein convertase subtilisin/kexin type 9 PCSK9 rs11206510. Conclusions The associations between cholesterol biomarkers and vitamin D metabolite levels in CIS are consistent with the biochemical inter-dependence between the two pathways. Cholesterol biomarkers should be considered for inclusion as covariates when assessing vitamin D levels in CIS. Objectives To investigate the mechanisms mediating the adverse effects of cholesterol in CIS and to determine the role of the nexus between the vitamin D3 (D3) and cholesterol pathways. Design Multi-center, prospective, longitudinal prospective study. Setting University hospital multiple sclerosis centers. Intervention Serum samples were obtained prior to any treatment from study subjects. Methods Serum obtained prior to any treatment from 172 CIS patients enrolled in a multi-center, prospective, longitudinal study (119 females: 53 males, age: 28.1 +- SD 8.1 years) were analyzed for high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (ApoAI), ApoAII, ApoB, ApoE, and lipoprotein-a. Levels of 25-hydroxy vitamin D3 (25(OH)D3), 1,25-dihydroxy D3, and 24,25-dihydroxy D3 were measured using liquid chromatography-mass spectrometry. Results Greater levels of HDL-C biomarkers (e.g., HDL-C itself, ApoAI, ApoAII and paroxonase arylesterase activity) and LDL-C biomarkers (e.g., LDL-C itself, Apo B) were associated with greater 25(OH)D3. The effects of HDL-C biomarkers were stronger than those of LDL-C. Free cholesterol and cholesteryl ester levels were positively associated with higher 25(OH)D3 levels. Cholesterol palmitate was particularly potent. The nexus between the D3 and cholesterol pathways was proximal to, or in linkage disequilibrium with, 7-dehydrocholesterol reductase DHCR7 rs1790349, endothelial lipase LIPG rs4939883 and proprotein convertase subtilisin/kexin type 9 PCSK9 rs11206510. Conclusions The associations between cholesterol biomarkers and vitamin D metabolite levels in CIS are consistent with the biochemical inter-dependence between the two pathways. Cholesterol biomarkers should be considered for inclusion as covariates when assessing vitamin D levels in CIS.
dcterms:title
Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study
skos:prefLabel
Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study
skos:notation
RIV/00216208:11110/14:10272303!RIV15-MSM-11110___
n3:aktivita
n10:Z n10:I n10:S
n3:aktivity
I, S, Z(MSM0021620849)
n3:cisloPeriodika
September
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n5:8895465 n5:8441456 n5:6857108 n5:4511042 n5:6253393 n5:8309213
n3:druhVysledku
n14:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
44564
n3:idVysledku
RIV/00216208:11110/14:10272303
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Vitamin D; Multiple sclerosis; Lipid; Interactions; Environmental factor; Clinically isolated syndromes; Cholesterol
n3:klicoveSlovo
n4:Cholesterol n4:Environmental%20factor n4:Vitamin%20D n4:Multiple%20sclerosis n4:Interactions n4:Clinically%20isolated%20syndromes n4:Lipid
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[9EDA8C4B1C74]
n3:nazevZdroje
Journal of Steroid Biochemistry and Molecular Biology
n3:obor
n17:FH
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
17
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
143
n3:tvurceVysledku
Qu, Jun Havrdová, Eva Bodziak, Mary Lou Zivadinov, Robert Bergsland, Niels Seidl, Zdeněk Ramasamy, Deepa P. Ramanathan, Murali Krásenský, Jan Vaněčková, Manuela Weinstock-Guttman, Bianca Badgett, Darlene Hagemeier, Jesper Tamano-Blanco, Miriam Browne, Richard W. Týblová, Michaela Horáková, Dana
n3:wos
000341465500046
n3:zamer
n19:MSM0021620849
s:issn
0960-0760
s:numberOfPages
10
n15:doi
10.1016/j.jsbmb.2014.06.007
n13:organizacniJednotka
11110