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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10272276%21RIV15-MSM-11110___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.jneuroim.2014.07.001
dcterms:description
The role of complement has been demonstrated in experimental models of neuromyelitis optica (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with disease activity, neurological disability and aquaporin-4 IgG in NMO patients suggesting a role of the alternative pathway of complement in the pathogenesis of NMO and supporting the strategy of therapeutic complement inhibition. The role of complement has been demonstrated in experimental models of neuromyelitis optica (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with disease activity, neurological disability and aquaporin-4 IgG in NMO patients suggesting a role of the alternative pathway of complement in the pathogenesis of NMO and supporting the strategy of therapeutic complement inhibition.
dcterms:title
Complement activation in patients with neuromyelitis optica Complement activation in patients with neuromyelitis optica
skos:prefLabel
Complement activation in patients with neuromyelitis optica Complement activation in patients with neuromyelitis optica
skos:notation
RIV/00216208:11110/14:10272276!RIV15-MSM-11110___
n3:aktivita
n16:S n16:I
n3:aktivity
I, S
n3:cisloPeriodika
1-2
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n12:3286371 n12:6609864 n12:6713157 n12:8441456 n12:8895465
n3:druhVysledku
n19:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
8333
n3:idVysledku
RIV/00216208:11110/14:10272276
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Neuromyelitis optica; Complement; C1q antibodies; Aquaporin-4 IgG
n3:klicoveSlovo
n13:C1q%20antibodies n13:Neuromyelitis%20optica n13:Complement n13:Aquaporin-4%20IgG
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[0302505CFD68]
n3:nazevZdroje
Journal of Neuroimmunology
n3:obor
n6:FH
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
274
n3:tvurceVysledku
Kemlink, David Havrdová, Eva Woodhall, Mark Horáková, Dana Waters, Patrick Vincent, Angela Trendelenburg, Marten Nytrová, Petra Živorová, Dana Potluková, Eliška
n3:wos
000342871600024
s:issn
0165-5728
s:numberOfPages
7
n10:doi
10.1016/j.jneuroim.2014.07.001
n11:organizacniJednotka
11110