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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10272060%21RIV15-MSM-11110___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2014/408683
dcterms:description
With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serumsamples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compared gene expression patterns of 36 samples. Twenty-four participants including 16 HNSCC patients (from 12 patients we obtained blood samples 1 year posttreatment) and 8 control subjects were recruited. The Illumina HumanWG-6 v3 Expression BeadChip was used to profile and identify the differences in serum mRNA transcriptomes. We found 159 genes to be significantly changed (Storey's.. value < 0.05) between normal and cancer serum specimens regardless of factors including p53 and B-cell lymphoma family members (Bcl-2, Bcl-XL). In contrast, there was no difference in gene expression between samples obtained before and after surgery in cancer patients. We suggest that microarray analysis of serum cRNA in patients with HNSCC should be suitable for refinement of early stage diagnosis of disease that can be important for development of new personalized strategies in diagnosis and treatment of tumours but is not suitable for monitoring further development of disease. With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serumsamples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compared gene expression patterns of 36 samples. Twenty-four participants including 16 HNSCC patients (from 12 patients we obtained blood samples 1 year posttreatment) and 8 control subjects were recruited. The Illumina HumanWG-6 v3 Expression BeadChip was used to profile and identify the differences in serum mRNA transcriptomes. We found 159 genes to be significantly changed (Storey's.. value < 0.05) between normal and cancer serum specimens regardless of factors including p53 and B-cell lymphoma family members (Bcl-2, Bcl-XL). In contrast, there was no difference in gene expression between samples obtained before and after surgery in cancer patients. We suggest that microarray analysis of serum cRNA in patients with HNSCC should be suitable for refinement of early stage diagnosis of disease that can be important for development of new personalized strategies in diagnosis and treatment of tumours but is not suitable for monitoring further development of disease.
dcterms:title
Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale
skos:prefLabel
Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale
skos:notation
RIV/00216208:11110/14:10272060!RIV15-MSM-11110___
n3:aktivita
n4:I n4:S
n3:aktivity
I, S
n3:cisloPeriodika
April
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n6:1963821 n6:2728729 n6:3337677 n6:3221105 n6:2818140 n6:6403190 n6:3468097 n6:9753346
n3:druhVysledku
n10:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
29150
n3:idVysledku
RIV/00216208:11110/14:10272060
n3:jazykVysledku
n9:eng
n3:klicovaSlova
marker; plasma; poor-prognosis; regulated genes; bh3-only proteins; stromal fibroblasts; differential expression; cisplatin-resistance; free nucleic-acids; breast-cancer patients
n3:klicoveSlovo
n5:breast-cancer%20patients n5:marker n5:differential%20expression n5:cisplatin-resistance n5:regulated%20genes n5:free%20nucleic-acids n5:plasma n5:stromal%20fibroblasts n5:poor-prognosis n5:bh3-only%20proteins
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CB7BF43BBA43]
n3:nazevZdroje
BioMed Research International
n3:obor
n11:FF
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
13
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
neuveden
n3:tvurceVysledku
Kolář, Michal Čada, Zdeněk Vlček, Čestmír Šáchová, Jana Strnad, Hynek Chovanec, Martin Smetana, Karel Hroudová, Miluše Valach, Jaroslav Čapková, Markéta Šteffl, Martin Plzák, Jan Kastner, Jan
n3:wos
000335235800001
s:issn
2314-6133
s:numberOfPages
10
n13:doi
10.1155/2014/408683
n14:organizacniJednotka
11110