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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10218645%21RIV15-MSM-11110___
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1177/1352458513507818
dcterms:description
Multiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing-remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS. Multiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing-remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS.
dcterms:title
Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study
skos:prefLabel
Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study
skos:notation
RIV/00216208:11110/14:10218645!RIV15-MSM-11110___
n3:aktivita
n16:I n16:Z
n3:aktivity
I, Z(MSM0021620849)
n3:cisloPeriodika
2
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n10:8895465
n3:druhVysledku
n14:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
13689
n3:idVysledku
RIV/00216208:11110/14:10218645
n3:jazykVysledku
n12:eng
n3:klicovaSlova
randomized controlled trial; glatiramer acetate; quality of life; dimethyl fumarate; BG-12; relapsing-remitting; Multiple sclerosis
n3:klicoveSlovo
n8:quality%20of%20life n8:relapsing-remitting n8:randomized%20controlled%20trial n8:dimethyl%20fumarate n8:glatiramer%20acetate n8:BG-12 n8:Multiple%20sclerosis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[588B403D536C]
n3:nazevZdroje
Multiple Sclerosis
n3:obor
n19:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
13
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
20
n3:tvurceVysledku
Zhang, Annie Sheikh, Sarah I. Havrdová, Eva Hutchinson, Michael Phillips, J. Theodore Kong, Jessica Fox, Robert J. Viglietta, Vissia Seidman, Emily Sarda, Sujata P. Dawson, Katherine T. Agarwal, Sonalee Kita, Mariko
n3:wos
000331226600019
n3:zamer
n17:MSM0021620849
s:issn
1352-4585
s:numberOfPages
5
n15:doi
10.1177/1352458513507818
n18:organizacniJednotka
11110