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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10210333%21RIV15-MSM-11110___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1093/cid/cit782
dcterms:description
Background. An increasing incidence of endemic hepatitis E (HE) has been reported in developed countries. Thus, an evaluation of the clinical characteristics of the disease and the utility of the current diagnostic methods is warranted. Methods. Fifty-one adult acute patients with HE hospitalized in a single center between the years 2009 and 2012 were evaluated. Serological and molecular techniques (detection of hepatitis E virus [HEV] RNA from stool and serum samples by quantitative reverse transcription polymerase chain reaction) with sequencing and phylogenetic analysis were used for diagnosis, and the clinical, laboratory, and epidemiological parameters of the patients were evaluated. Results. Forty-nine (96.1%) patients had acute endemic HE and 2 (3.9%) had an imported infection. In the cohort of patients with acute symptomatic HE (n = 47), men outnumbered women (40:7), the patients were in older middle age (mean, 60.57 years), and they had elevated median values of total bilirubin (6.67 mg/dL), alanine aminotransferase (2288.82 U/L), aspartate aminotransferase (1251.76 U/L), gamma-glutamyl transferase (360.53 U/L), and alkaline phosphatase (197.06 U/L). Serology was positive in 50 (98%) of the patients, and 1 case was diagnosed by polymerase chain reaction only. HEV RNA was detected in at least 1 specimen from 84.3% of the patients, and 28 of 29 tested isolates belonged to genotype 3. The eating of meat, innards, other home-prepared pork products, or the tasting of raw meat before cooking were the most frequently reported data (reported by 25 patients [49.0%]). Conclusions. Large numbers of the endemic cases of HE were caused by HEV genotype 3, and the clinical characteristics of endemic HE were demonstrated. Background. An increasing incidence of endemic hepatitis E (HE) has been reported in developed countries. Thus, an evaluation of the clinical characteristics of the disease and the utility of the current diagnostic methods is warranted. Methods. Fifty-one adult acute patients with HE hospitalized in a single center between the years 2009 and 2012 were evaluated. Serological and molecular techniques (detection of hepatitis E virus [HEV] RNA from stool and serum samples by quantitative reverse transcription polymerase chain reaction) with sequencing and phylogenetic analysis were used for diagnosis, and the clinical, laboratory, and epidemiological parameters of the patients were evaluated. Results. Forty-nine (96.1%) patients had acute endemic HE and 2 (3.9%) had an imported infection. In the cohort of patients with acute symptomatic HE (n = 47), men outnumbered women (40:7), the patients were in older middle age (mean, 60.57 years), and they had elevated median values of total bilirubin (6.67 mg/dL), alanine aminotransferase (2288.82 U/L), aspartate aminotransferase (1251.76 U/L), gamma-glutamyl transferase (360.53 U/L), and alkaline phosphatase (197.06 U/L). Serology was positive in 50 (98%) of the patients, and 1 case was diagnosed by polymerase chain reaction only. HEV RNA was detected in at least 1 specimen from 84.3% of the patients, and 28 of 29 tested isolates belonged to genotype 3. The eating of meat, innards, other home-prepared pork products, or the tasting of raw meat before cooking were the most frequently reported data (reported by 25 patients [49.0%]). Conclusions. Large numbers of the endemic cases of HE were caused by HEV genotype 3, and the clinical characteristics of endemic HE were demonstrated.
dcterms:title
Endemic Hepatitis E in the Czech Republic Endemic Hepatitis E in the Czech Republic
skos:prefLabel
Endemic Hepatitis E in the Czech Republic Endemic Hepatitis E in the Czech Republic
skos:notation
RIV/00216208:11110/14:10210333!RIV15-MSM-11110___
n4:aktivita
n11:Z n11:I n11:P
n4:aktivity
I, P(ED0006/01/01), P(NT13884), Z(MZE0002716202)
n4:cisloPeriodika
4
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n5:6737374 n5:5649617
n4:druhVysledku
n17:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
14518
n4:idVysledku
RIV/00216208:11110/14:10210333
n4:jazykVysledku
n18:eng
n4:klicovaSlova
zoonosis; clinical findings; endemic cases; hepatitis E
n4:klicoveSlovo
n9:clinical%20findings n9:hepatitis%20E n9:zoonosis n9:endemic%20cases
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[7955DA8C9BF3]
n4:nazevZdroje
Clinical Infectious Diseases
n4:obor
n19:FN
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:projekt
n12:ED0006%2F01%2F01 n12:NT13884
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
58
n4:tvurceVysledku
Pavlik, Ivo Chalupa, Pavel Vasickova, Petra Holub, Michal
n4:wos
000331097800011
n4:zamer
n20:MZE0002716202
s:issn
1058-4838
s:numberOfPages
8
n21:doi
10.1093/cid/cit782
n13:organizacniJednotka
11110