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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10189985%21RIV15-MSM-11110___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/cen.12298
dcterms:description
Objective Iodine deficiency is associated with thyroid dysfunction and adverse pregnancy outcomes. The aim of our study was to investigate the status of iodine saturation in women after spontaneous abortion (SpA) residing in an iodine-sufficient area and to evaluate their subsequent reproductive health. Design Nonrandomized prospective follow-up study. Patients and methods We compared urinary iodine concentration (UIC) in 171 women 2-8 weeks (median 4) after an early SpA with age-matched controls. Women with known thyroid diseases were excluded. We also analysed a relationship of UIC to serum thyroid-stimulating hormone, free thyroxine, antibodies against thyroid peroxidase and thyroid ultrasound. Afterwards, we followed the women for a median of 38 months (range 12-47). We used a multivariate regression analysis to assess the influence of iodine status and other thyroid biochemical and ultrasound parameters on their subsequent reproductive health. Results Women after SpA were almost twice as likely to suffer from mild iodine deficiency and had lower median UIC as compared to age-matched controls [rate 105/181 (580%) vs 57/181 (315%), P < 0001, medians UIC 9200 vs 11780 mcg/l, P < 0001]. UIC was not influenced by the use of iodine supplements in the previous pregnancy. We did not find any association neither between UIC and thyroid dysfunction and/or thyroid antibodies, nor between UIC and rates of subsequent successful pregnancies or obstetric complications. Conclusions More than half of women after SpA residing in an iodine-sufficient area are suffering from mild iodine deficiency. However, it does not seem to have a negative impact on their subsequent reproductive health. Objective Iodine deficiency is associated with thyroid dysfunction and adverse pregnancy outcomes. The aim of our study was to investigate the status of iodine saturation in women after spontaneous abortion (SpA) residing in an iodine-sufficient area and to evaluate their subsequent reproductive health. Design Nonrandomized prospective follow-up study. Patients and methods We compared urinary iodine concentration (UIC) in 171 women 2-8 weeks (median 4) after an early SpA with age-matched controls. Women with known thyroid diseases were excluded. We also analysed a relationship of UIC to serum thyroid-stimulating hormone, free thyroxine, antibodies against thyroid peroxidase and thyroid ultrasound. Afterwards, we followed the women for a median of 38 months (range 12-47). We used a multivariate regression analysis to assess the influence of iodine status and other thyroid biochemical and ultrasound parameters on their subsequent reproductive health. Results Women after SpA were almost twice as likely to suffer from mild iodine deficiency and had lower median UIC as compared to age-matched controls [rate 105/181 (580%) vs 57/181 (315%), P < 0001, medians UIC 9200 vs 11780 mcg/l, P < 0001]. UIC was not influenced by the use of iodine supplements in the previous pregnancy. We did not find any association neither between UIC and thyroid dysfunction and/or thyroid antibodies, nor between UIC and rates of subsequent successful pregnancies or obstetric complications. Conclusions More than half of women after SpA residing in an iodine-sufficient area are suffering from mild iodine deficiency. However, it does not seem to have a negative impact on their subsequent reproductive health.
dcterms:title
Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health
skos:prefLabel
Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health
skos:notation
RIV/00216208:11110/14:10189985!RIV15-MSM-11110___
n5:aktivita
n16:I
n5:aktivity
I
n5:cisloPeriodika
3
n5:dodaniDat
n14:2015
n5:domaciTvurceVysledku
n6:6492789 n6:1258524 n6:9234322 n6:7238495 n6:3648893 n6:3841618 n6:6713157
n5:druhVysledku
n13:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
29387
n5:idVysledku
RIV/00216208:11110/14:10189985
n5:jazykVysledku
n11:eng
n5:klicovaSlova
impact reproductive health; Czech Republic; spontaneous abortions; women; Mild iodine deficiency
n5:klicoveSlovo
n8:spontaneous%20abortions n8:Mild%20iodine%20deficiency n8:impact%20reproductive%20health n8:Czech%20Republic n8:women
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[817737707426]
n5:nazevZdroje
Clinical Endocrinology
n5:obor
n15:FB
n5:pocetDomacichTvurcuVysledku
7
n5:pocetTvurcuVysledku
10
n5:rokUplatneniVysledku
n14:2014
n5:svazekPeriodika
80
n5:tvurceVysledku
Krátký, Jan Telička, Zdeněk Zamrazil, Václav Bartáková, Jana Jiskra, Jan Lukáš, Jindřich Potluková, Eliška Fait, Tomáš Límanová, Zdeňka Bílek, Radovan
n5:wos
000337193000021
s:issn
0300-0664
s:numberOfPages
7
n19:doi
10.1111/cen.12298
n9:organizacniJednotka
11110