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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10210260%21RIV14-MPO-11110___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://www.chemicke-listy.cz/docs/full/2013_s3_s420-s453.pdf
dcterms:description
Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) - adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diagnostic markers of this tumour. Determination of metanephrines is often preferred against determination of catecholamines regarding the diagnosis of PHEO. Tumour cells produce free metanephrines continuously and irrespective of the release of catecholamines. The project aims to develop a new kit for the determination of plasma metanephrines. Solid phase extraction (SPE) was used for the pre-treatment of plasma samples. The determination was performed by high performance liquid chromatography with electrochemical detection (HPLC-ED). Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) - adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diagnostic markers of this tumour. Determination of metanephrines is often preferred against determination of catecholamines regarding the diagnosis of PHEO. Tumour cells produce free metanephrines continuously and irrespective of the release of catecholamines. The project aims to develop a new kit for the determination of plasma metanephrines. Solid phase extraction (SPE) was used for the pre-treatment of plasma samples. The determination was performed by high performance liquid chromatography with electrochemical detection (HPLC-ED).
dcterms:title
PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA
skos:prefLabel
PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA PLASMA FREE METANEPHRINES AS DIAGNOSTIC MARKERS OF PHEOCHROMOCYTOMA
skos:notation
RIV/00216208:11110/13:10210260!RIV14-MPO-11110___
n13:predkladatel
n14:orjk%3A11110
n4:aktivita
n7:P n7:V
n4:aktivity
P(FR-TI4/331), V
n4:cisloPeriodika
Supplement 3
n4:dodaniDat
n10:2014
n4:domaciTvurceVysledku
n16:2203278
n4:druhVysledku
n8:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
96408
n4:idVysledku
RIV/00216208:11110/13:10210260
n4:jazykVysledku
n20:eng
n4:klicovaSlova
PHEOCHROMOCYTOMA; MARKERS; DIAGNOSTIC; PLASMA FREE METANEPHRINES
n4:klicoveSlovo
n6:PHEOCHROMOCYTOMA n6:DIAGNOSTIC n6:PLASMA%20FREE%20METANEPHRINES n6:MARKERS
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[00D23726ADE0]
n4:nazevZdroje
Chemické listy
n4:obor
n18:CB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:projekt
n17:FR-TI4%2F331
n4:rokUplatneniVysledku
n10:2013
n4:svazekPeriodika
107
n4:tvurceVysledku
Bartos, Michal Nyvltova, Zora Pilarova, Michaela Brabcová Vránková, Alice Portychova, Lenka Horna, Ales Antal, Miroslav Vermousek, Ivan
n4:wos
000328730800056
s:issn
0009-2770
s:numberOfPages
3
n15:organizacniJednotka
11110