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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10209647%21RIV14-GA0-11110___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://fb.cuni.cz/file/5703/FB2013A0030.pdf
dcterms:description
Data about the possible correlation between reduction of the regeneration capacity in the course of phylogeny and formation of malignant tumours have been summarized from invertebrates to mammals. The evolutionarily increasing complexity of body building plane and expectancy of longevity in the course of phylogeny seems to be grossly negatively correlated with diminished regeneration capacity, but positively with increased occurrence of malignant tumours. A certain evolution-based switch-off mechanism reducing the extent of regeneration in developmentally complicated and long-living animals such as mammals and birds can be hypothesized and benefits of loss of this ability are discussed. This high incidence of malignancies seems to be related, in addition to other factors, to prolonged and cumulative exposure to cancerogenic stimuli in the course of lifetime. Longevity, supported by the progress and availability of medical care to the population, has been unveiling this phenomenon during recent decades. From this point of view, ageing represents the main risk for cancer acquisition. The probable role of microenvironment in all the discussed phenomena such as healing/regeneration, inflammation, and cancer is discussed and targeting of microenvironment is consequently predicted as a possible therapeutic target where controlled manipulation may represent a new approach to the treatment of cancer patients. Data about the possible correlation between reduction of the regeneration capacity in the course of phylogeny and formation of malignant tumours have been summarized from invertebrates to mammals. The evolutionarily increasing complexity of body building plane and expectancy of longevity in the course of phylogeny seems to be grossly negatively correlated with diminished regeneration capacity, but positively with increased occurrence of malignant tumours. A certain evolution-based switch-off mechanism reducing the extent of regeneration in developmentally complicated and long-living animals such as mammals and birds can be hypothesized and benefits of loss of this ability are discussed. This high incidence of malignancies seems to be related, in addition to other factors, to prolonged and cumulative exposure to cancerogenic stimuli in the course of lifetime. Longevity, supported by the progress and availability of medical care to the population, has been unveiling this phenomenon during recent decades. From this point of view, ageing represents the main risk for cancer acquisition. The probable role of microenvironment in all the discussed phenomena such as healing/regeneration, inflammation, and cancer is discussed and targeting of microenvironment is consequently predicted as a possible therapeutic target where controlled manipulation may represent a new approach to the treatment of cancer patients.
dcterms:title
Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation
skos:prefLabel
Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation
skos:notation
RIV/00216208:11110/13:10209647!RIV14-GA0-11110___
n16:predkladatel
n17:orjk%3A11110
n3:aktivita
n11:P n11:I
n3:aktivity
I, P(GAP304/12/1333)
n3:cisloPeriodika
6
n3:dodaniDat
n9:2014
n3:domaciTvurceVysledku
n15:6406920 n15:7922795 n15:3221105
n3:druhVysledku
n7:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
96157
n3:idVysledku
RIV/00216208:11110/13:10209647
n3:jazykVysledku
n20:eng
n3:klicovaSlova
mesenchymal transition; dna-damage; tumor stroma; limb regeneration; stromal fibroblasts; tissue regeneration; naked mole-rat; newt cynops-pyrrhogaster; adult stem-cells; squamous-cell carcinoma
n3:klicoveSlovo
n6:newt%20cynops-pyrrhogaster n6:mesenchymal%20transition n6:tissue%20regeneration n6:tumor%20stroma n6:adult%20stem-cells n6:naked%20mole-rat n6:squamous-cell%20carcinoma n6:stromal%20fibroblasts n6:dna-damage n6:limb%20regeneration
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[774D943A1D87]
n3:nazevZdroje
Folia Biologica
n3:obor
n8:EA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n12:GAP304%2F12%2F1333
n3:rokUplatneniVysledku
n9:2013
n3:svazekPeriodika
59
n3:tvurceVysledku
Dvořánková, Barbora Lacina, Lukáš Smetana, Karel
n3:wos
000330161600001
s:issn
0015-5500
s:numberOfPages
10
n19:organizacniJednotka
11110