This HTML5 document contains 66 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n14http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11110%2F13%3A10196424%21RIV14-MSM-11110___/
dctermshttp://purl.org/dc/terms/
n12http://localhost/temp/predkladatel/
n20http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n16http://linked.opendata.cz/resource/domain/vavai/subjekt/
n5http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
rdfshttp://www.w3.org/2000/01/rdf-schema#
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n19http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10196424%21RIV14-MSM-11110___
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1371/journal.ppat.1003776
dcterms:description
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env-specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals, augmented transcytosis across epithelial cells as much as 20-fold compared with Env-specific IgG at neutral pH or non-specific IgG at either pH. Enhanced transcytosis was observed with clinical HIV-1 isolates, including transmitted/founder strains, and was eliminated in Fc neonatal receptor (FcRn)-knockdown epithelial cells. Non-neutralizing antibodies allowed similar or less transcytosis than neutralizing antibodies. However, the ratio of total: infectious virus was higher for neutralizing antibodies, indicating that they allowed transcytosis while blocking infectivity of transcytosed virus. Immunocytochemistry revealed abundant FcRn expression in columnar epithelia lining the human endocervix and penile urethra. Acidity and Env-specific IgG enhance transcytosis of virus across epithelial cells via FcRn and could facilitate translocation of virus to susceptible target cells following sexual exposure. The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env-specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals, augmented transcytosis across epithelial cells as much as 20-fold compared with Env-specific IgG at neutral pH or non-specific IgG at either pH. Enhanced transcytosis was observed with clinical HIV-1 isolates, including transmitted/founder strains, and was eliminated in Fc neonatal receptor (FcRn)-knockdown epithelial cells. Non-neutralizing antibodies allowed similar or less transcytosis than neutralizing antibodies. However, the ratio of total: infectious virus was higher for neutralizing antibodies, indicating that they allowed transcytosis while blocking infectivity of transcytosed virus. Immunocytochemistry revealed abundant FcRn expression in columnar epithelia lining the human endocervix and penile urethra. Acidity and Env-specific IgG enhance transcytosis of virus across epithelial cells via FcRn and could facilitate translocation of virus to susceptible target cells following sexual exposure.
dcterms:title
The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells
skos:prefLabel
The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells
skos:notation
RIV/00216208:11110/13:10196424!RIV14-MSM-11110___
n5:predkladatel
n16:orjk%3A11110
n3:aktivita
n7:I n7:V
n3:aktivity
I, V
n3:cisloPeriodika
11
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n20:8324514
n3:druhVysledku
n10:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
91344
n3:idVysledku
RIV/00216208:11110/13:10196424
n3:jazykVysledku
n18:eng
n3:klicovaSlova
vaginal ph; human placenta; cervical ectopy; mediated presentation; 1-infected individuals; hiv-1-infected individuals; dendritic cells; monoclonal-antibodies; female genital-tract; antibody-dependent enhancement
n3:klicoveSlovo
n9:1-infected%20individuals n9:dendritic%20cells n9:human%20placenta n9:cervical%20ectopy n9:monoclonal-antibodies n9:antibody-dependent%20enhancement n9:mediated%20presentation n9:female%20genital-tract n9:hiv-1-infected%20individuals n9:vaginal%20ph
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[232FC8E8DD5C]
n3:nazevZdroje
PLoS Pathogens [online]
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
19
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
9
n3:tvurceVysledku
Corti, Davide Phan, Tran B. Městecký, Jiří Joseph, Sarah B. Ping, Li-Hua Lanzavecchia, Antonio Ruprecht, Ruth M. Moldoveanu, Zina Hel, Zdenek Anderson, Deborah J. Landucci, Gary Pudney, Jeffrey Becerra, Juan C. Moldt, Brian Gach, Johannes S. Burton, Dennis R. Forthal, Donald N. Supnet, Medalyn Jude Gupta, Sandeep
n3:wos
000330386900035
s:issn
1553-7374
s:numberOfPages
12
n19:doi
10.1371/journal.ppat.1003776
n12:organizacniJednotka
11110