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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10195055%21RIV14-MZ0-11110___
rdf:type
skos:Concept n20:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2013/864319
dcterms:description
This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers. This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.
dcterms:title
Pharmacogenetics of Chronic Pain and Its Treatment Pharmacogenetics of Chronic Pain and Its Treatment
skos:prefLabel
Pharmacogenetics of Chronic Pain and Its Treatment Pharmacogenetics of Chronic Pain and Its Treatment
skos:notation
RIV/00216208:11110/13:10195055!RIV14-MZ0-11110___
n20:predkladatel
n21:orjk%3A11110
n4:aktivita
n6:P n6:I
n4:aktivity
I, P(NT11324)
n4:cisloPeriodika
2013
n4:dodaniDat
n12:2014
n4:domaciTvurceVysledku
n11:8164401 n11:5539838 n11:5781752 n11:1998005 n11:1547801
n4:druhVysledku
n19:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
95994
n4:idVysledku
RIV/00216208:11110/13:10195055
n4:jazykVysledku
n10:eng
n4:klicovaSlova
tumor-necrosis-factor; p-glycoprotein inhibition; single-nucleotide polymorphism; serotonin transporter gene; nonsteroidal antiinflammatory drugs; opioid receptor gene; blood-brain-barrier; catechol-o-methyltransferase
n4:klicoveSlovo
n7:tumor-necrosis-factor n7:p-glycoprotein%20inhibition n7:catechol-o-methyltransferase n7:serotonin%20transporter%20gene n7:opioid%20receptor%20gene n7:nonsteroidal%20antiinflammatory%20drugs n7:blood-brain-barrier n7:single-nucleotide%20polymorphism
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[CCF90EAD2164]
n4:nazevZdroje
Mediators of Inflammation
n4:obor
n13:EC
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n14:NT11324
n4:rokUplatneniVysledku
n12:2013
n4:svazekPeriodika
Neuveden
n4:tvurceVysledku
Bakhouche, Hana Matoušková, Olga Hronová, Karolína Slanař, Ondřej Světlík, Svatopluk
n4:wos
000319931000001
s:issn
0962-9351
s:numberOfPages
23
n18:doi
10.1155/2013/864319
n15:organizacniJednotka
11110