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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10194767%21RIV14-GA0-11110___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.colsurfb.2013.03.059
dcterms:description
Stable vesicles for efficient curcumin encapsulation, delivery and controlled release have been obtained by coating ofliposomes with thin layer of newly synthesized chitosan derivatives. Three different derivatives of chitosan were obtained and studied: the cationic (by introduction of the stable, quaternary ammonium groups), the hydrophobic (by attachment of N-dodecyl groups) and cationic-hydrophobic one (containing both quaternary ammonium and N-dodecyl groups). Zeta potential measurements confirmed effective coating of liposomes with all these chitosan derivatives. The liposomes coated with cationic-hydrophobic chitosan derivative are the most promising curcumin carriers; they can easily penetrate cell membrane and release curcumin in a controlled manner. Biological studies indicated that such systems are non-toxic for murine fibroblasts (NIH3T3) while toxic toward murine melanoma (B16F10) cell line. Stable vesicles for efficient curcumin encapsulation, delivery and controlled release have been obtained by coating ofliposomes with thin layer of newly synthesized chitosan derivatives. Three different derivatives of chitosan were obtained and studied: the cationic (by introduction of the stable, quaternary ammonium groups), the hydrophobic (by attachment of N-dodecyl groups) and cationic-hydrophobic one (containing both quaternary ammonium and N-dodecyl groups). Zeta potential measurements confirmed effective coating of liposomes with all these chitosan derivatives. The liposomes coated with cationic-hydrophobic chitosan derivative are the most promising curcumin carriers; they can easily penetrate cell membrane and release curcumin in a controlled manner. Biological studies indicated that such systems are non-toxic for murine fibroblasts (NIH3T3) while toxic toward murine melanoma (B16F10) cell line.
dcterms:title
Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives
skos:prefLabel
Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives
skos:notation
RIV/00216208:11110/13:10194767!RIV14-GA0-11110___
n16:predkladatel
n21:orjk%3A11110
n4:aktivita
n15:I n15:P
n4:aktivity
I, P(GBP302/12/G157)
n4:cisloPeriodika
9
n4:dodaniDat
n5:2014
n4:domaciTvurceVysledku
n9:7766319
n4:druhVysledku
n19:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
67507
n4:idVysledku
RIV/00216208:11110/13:10194767
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Carrier; Coating; Liposome; Curcumin; Chitosan derivative
n4:klicoveSlovo
n6:Chitosan%20derivative n6:Coating n6:Liposome n6:Curcumin n6:Carrier
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[F16B71CEA7A6]
n4:nazevZdroje
Colloids and Surfaces B: Biointerfaces
n4:obor
n12:JI
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:projekt
n8:GBP302%2F12%2FG157
n4:rokUplatneniVysledku
n5:2013
n4:svazekPeriodika
109
n4:tvurceVysledku
Dulak, Jozef Jozkowicz, Alicja Nowakowska, Maria Karewicz, Anna Gzyl-Malcher, Barbara Bednár, Ján Loboda, Agnieszka Bielska, Dorota
n4:wos
000320413300044
s:issn
0927-7765
s:numberOfPages
10
n18:doi
10.1016/j.colsurfb.2013.03.059
n13:organizacniJednotka
11110