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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10192278%21RIV14-MSM-11110___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1042/CS20120661
dcterms:description
Recent epidemiological and clinical data show protection from CVD, all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low- and pro-atherogenic LDL subfractions (LDL-1 + LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentrations (P = 0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P < 0.05; Apo-B: P < 0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29 +/- 0.38 compared with 1.27 +/- 0.72 mM; P < 0.001) and TAG (1.66 +/- 0.67 compared with 0.99 +/- 0.52 mM; P < 0.001) concentrations compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans. Recent epidemiological and clinical data show protection from CVD, all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low- and pro-atherogenic LDL subfractions (LDL-1 + LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentrations (P = 0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P < 0.05; Apo-B: P < 0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29 +/- 0.38 compared with 1.27 +/- 0.72 mM; P < 0.001) and TAG (1.66 +/- 0.67 compared with 0.99 +/- 0.52 mM; P < 0.001) concentrations compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans.
dcterms:title
Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
skos:prefLabel
Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
skos:notation
RIV/00216208:11110/13:10192278!RIV14-MSM-11110___
n13:predkladatel
n14:orjk%3A11110
n3:aktivita
n18:N
n3:aktivity
N
n3:cisloPeriodika
5-6
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n4:2025876
n3:druhVysledku
n19:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
100507
n3:idVysledku
RIV/00216208:11110/13:10192278
n3:jazykVysledku
n6:eng
n3:klicovaSlova
unconjugated bilirubin; lipid metabolism; low-density lipoprotein (LDL)-subfractions; Gilbert's syndrome; cardiovascular disease (CVD); apolipoprotein
n3:klicoveSlovo
n8:Gilbert%27s%20syndrome n8:lipid%20metabolism n8:low-density%20lipoprotein%20%28LDL%29-subfractions n8:apolipoprotein n8:cardiovascular%20disease%20%28CVD%29 n8:unconjugated%20bilirubin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0990781D2C61]
n3:nazevZdroje
Clinical Science
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
125
n3:tvurceVysledku
Wallner, Marlies Wagner, Oswald Marculescu, Rodrig Bulmer, Andrew C. Doberer, Daniel Vítek, Libor Wolzt, Michael Wagner, Karl-Heinz
n3:wos
000322504400004
s:issn
0143-5221
s:numberOfPages
8
n10:doi
10.1042/CS20120661
n20:organizacniJednotka
11110