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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10191824%21RIV14-MZ0-11110___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.5772/55191
dcterms:description
Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage. Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage.
dcterms:title
MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network
skos:prefLabel
MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network
skos:notation
RIV/00216208:11110/13:10191824!RIV14-MZ0-11110___
n14:predkladatel
n15:orjk%3A11110
n3:aktivita
n22:I n22:P
n3:aktivity
I, P(NT11229)
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n13:1315145 n13:8244618
n3:druhVysledku
n4:C
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
88556
n3:idVysledku
RIV/00216208:11110/13:10191824
n3:jazykVysledku
n10:eng
n3:klicovaSlova
transcription factor, SWI/SNF; microphthalmia, MITF; melanoma
n3:klicoveSlovo
n6:SWI%2FSNF n6:MITF n6:transcription%20factor n6:melanoma n6:microphthalmia
n3:kontrolniKodProRIV
[887804A66076]
n3:mistoVydani
Rijeka, Croatia
n3:nazevEdiceCisloSvazku
Neuveden
n3:nazevZdroje
Recent Advances in the Biology, Therapy and Management of Melanoma
n3:obor
n23:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetStranKnihy
375
n3:pocetTvurcuVysledku
2
n3:projekt
n7:NT11229
n3:rokUplatneniVysledku
n5:2013
n3:tvurceVysledku
Ondrušová, Ľubica Vachtenheim, Jiří
s:numberOfPages
11
n12:doi
10.5772/55191
n18:hasPublisher
InTech
n9:isbn
978-953-51-0976-1
n20:organizacniJednotka
11110