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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10190400%21RIV14-GA0-11110___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/gcc.22058/pdf
dcterms:description
Chromosome 11 abnormalities are found in many hematological malignancies. In acute myeloid leukemia (AML), a proto-oncogene MLL (11q23.3) is frequently altered. However, rearrangements involving other regions of chromosome 11 have been reported. Therefore, we have characterized the chromosome 11 breakpoints and common deleted and amplified areas in the bone marrow or peripheral blood cells of newly diagnosed patients with AML. Using molecularcytogenetic methods (multicolor fluorescence in situ hybridization (mFISH), multicolor banding (mBAND), microarrays, and FISH with bacterial artificial chromosome (BAC) probes, chromosome 11 abnormalities were delineated in 54 out of 300 (18%) newly diagnosed AML patients. At least 36 different chromosome 11 breakpoints were identified; two were recurrent (11p15.4 in the NUP98 gene and 11q23.3 in the MLL gene), and three were possibly nonrandom: 11p13 (ch11:29.31-31.80 Mb), 11p12 (ch11:36.75-37.49 Mb) and 11q13.2 (68.31-68.52 Mb). One new MLL gene rearrangement is also described. No commonly deleted region of chromosome 11 was identified. However, some regions were affected more often: 11pter-11p15.5 (n = 4; ch11:0-3.52 Mb), 11p14.1-11p13 (n = 4; ch11:28.00-31.00 Mb) and 11p13 (n = 4; ch11:31.00-31.50 Mb). One commonly duplicated (3 copies) region was identified in chromosomal band 11q23.3-11q24 (n = 9; ch11:118.35-125.00 Mb). In all eight cases of 11q amplification (>3 copies), only the 5 part of the MLL gene was affected. This study highlights several chromosome 11 loci that might be important for the leukemogeneic process in AML. Chromosome 11 abnormalities are found in many hematological malignancies. In acute myeloid leukemia (AML), a proto-oncogene MLL (11q23.3) is frequently altered. However, rearrangements involving other regions of chromosome 11 have been reported. Therefore, we have characterized the chromosome 11 breakpoints and common deleted and amplified areas in the bone marrow or peripheral blood cells of newly diagnosed patients with AML. Using molecularcytogenetic methods (multicolor fluorescence in situ hybridization (mFISH), multicolor banding (mBAND), microarrays, and FISH with bacterial artificial chromosome (BAC) probes, chromosome 11 abnormalities were delineated in 54 out of 300 (18%) newly diagnosed AML patients. At least 36 different chromosome 11 breakpoints were identified; two were recurrent (11p15.4 in the NUP98 gene and 11q23.3 in the MLL gene), and three were possibly nonrandom: 11p13 (ch11:29.31-31.80 Mb), 11p12 (ch11:36.75-37.49 Mb) and 11q13.2 (68.31-68.52 Mb). One new MLL gene rearrangement is also described. No commonly deleted region of chromosome 11 was identified. However, some regions were affected more often: 11pter-11p15.5 (n = 4; ch11:0-3.52 Mb), 11p14.1-11p13 (n = 4; ch11:28.00-31.00 Mb) and 11p13 (n = 4; ch11:31.00-31.50 Mb). One commonly duplicated (3 copies) region was identified in chromosomal band 11q23.3-11q24 (n = 9; ch11:118.35-125.00 Mb). In all eight cases of 11q amplification (>3 copies), only the 5 part of the MLL gene was affected. This study highlights several chromosome 11 loci that might be important for the leukemogeneic process in AML.
dcterms:title
Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia
skos:prefLabel
Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia
skos:notation
RIV/00216208:11110/13:10190400!RIV14-GA0-11110___
n13:predkladatel
n14:orjk%3A11110
n4:aktivita
n5:I n5:P
n4:aktivity
I, P(GBP302/12/G157), P(OC10043)
n4:cisloPeriodika
7
n4:dodaniDat
n10:2014
n4:domaciTvurceVysledku
n12:1588656 n12:1129244 n12:8307946 n12:7931360 n12:7529805
n4:druhVysledku
n11:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
65062
n4:idVysledku
RIV/00216208:11110/13:10190400
n4:jazykVysledku
n19:eng
n4:klicovaSlova
aCGH; mBAND; mFISH; FISH; complex karyotype; cryptic rearrangement; MLL; NUP98; acute myeloid leukemia (AML); chromosome 11
n4:klicoveSlovo
n6:FISH n6:acute%20myeloid%20leukemia%20%28AML%29 n6:MLL n6:aCGH n6:cryptic%20rearrangement n6:mBAND n6:mFISH n6:complex%20karyotype n6:NUP98 n6:chromosome%2011
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[F28C0A14EA1E]
n4:nazevZdroje
Genes Chromosomes and Cancer
n4:obor
n16:EB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
10
n4:projekt
n17:OC10043 n17:GBP302%2F12%2FG157
n4:rokUplatneniVysledku
n10:2013
n4:svazekPeriodika
52
n4:tvurceVysledku
Zemanová, Zuzana Vydra, Jan Šárová, Iveta Bystřická, Dagmar Krejcik, Zdenek Jonášová, Anna Cermak, Jaroslav Brezinova, Jana Soukup, Petr Michalová, Kyra
n4:wos
000318989600003
s:issn
1045-2257
s:numberOfPages
17
n18:organizacniJednotka
11110