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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10189993%21RIV14-MZ0-11110___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/jsr.12047
dcterms:description
In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n=216) and without cataplexy (n=33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P<0.001) and had a higher body mass index (BMI) prior to pregnancy (P<0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P<0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P<0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult. In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n=216) and without cataplexy (n=33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P<0.001) and had a higher body mass index (BMI) prior to pregnancy (P<0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P<0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P<0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.
dcterms:title
Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies
skos:prefLabel
Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies
skos:notation
RIV/00216208:11110/13:10189993!RIV14-MZ0-11110___
n14:predkladatel
n15:orjk%3A11110
n4:aktivita
n13:V n13:Z n13:P n13:I
n4:aktivity
I, P(NT13238), V, Z(MSM0021620849)
n4:cisloPeriodika
5
n4:dodaniDat
n7:2014
n4:domaciTvurceVysledku
n8:2043718 n8:3286371 n8:9725652 n8:5374677
n4:druhVysledku
n16:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n22:predkladatel
n4:idSjednocenehoVysledku
90669
n4:idVysledku
RIV/00216208:11110/13:10189993
n4:jazykVysledku
n20:eng
n4:klicovaSlova
puerperium; pregnancy; newborn; metabolism; delivery; cataplexy
n4:klicoveSlovo
n5:cataplexy n5:puerperium n5:pregnancy n5:delivery n5:newborn n5:metabolism
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[BB565C23983F]
n4:nazevZdroje
Journal of Sleep Research
n4:obor
n10:FH
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
28
n4:projekt
n17:NT13238
n4:rokUplatneniVysledku
n7:2013
n4:svazekPeriodika
22
n4:tvurceVysledku
Ferini-Strambi, Luigi Ettenhuber, Katharina Riha, Renata L. Van der Heide, Astrid Wierzbicka, Aleksandra Poli, Francesca Kemlink, David Leonthin, Helle Nevšímalová, Soňa Ehrmann, Laura Arnulf, Isabelle Peraita-Adrados, Rosa Geisler, Peter Maurovich Horvath, Eszter Lammers, Gert Jan Beitinger, Pierre A. Hoegl, Birgit Jennum, Poul Puertas, Francisco J. Mathis, Johannes Slonkova, Jana Calvo, Elena Plazzi, Giuseppe Tormasiova, Maria Mayer, Geert Frauscher, Birgit Dauvilliers, Yves Šonka, Karel
n4:wos
000324335300003
n4:zamer
n19:MSM0021620849
s:issn
0962-1105
s:numberOfPages
17
n18:doi
10.1111/jsr.12047
n21:organizacniJednotka
11110