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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10189436%21RIV14-MSM-11110___
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.bbmt.2013.02.012
dcterms:description
Significant controversy exists regarding the impact of hematopoietic stroma damage by irradiation on the efficiency of engraftment of intravenously transplanted stem cells. It was previously demonstrated that in normal syngenic mice, all intravenously transplanted donor stem cells, present in the bone marrow, compete equally with those of the host. In this study, we comprehensively compared the blood cell production derived from transplanted donor stem cells with that from the host stem cells surviving various doses of submyeloablative irradiation. We compared the partial chimerism resulting from transplantation with theoretical estimates that assumed transplantation efficiencies ranging from 100% to 20%. The highest level of consensus between the experimental and the theoretical results was 100% for homing and engraftment (ie, the utilization of all transplanted stem cells). These results point to a very potent mechanism through which intravenously administered hematopoietic stem cells are captured from circulation, engraft in the hematopoietic tissue, and contribute to blood cell production in irradiated recipients. The damage done to hematopoietic stroma and to the trabecular bone by submyeloablative doses of ionizing radiation does not negatively affect the homing and engraftment mechanisms of intravenously transplanted hematopoietic progenitor and stem cells. (C) 2013 American Society for Blood and Marrow Transplantation. Significant controversy exists regarding the impact of hematopoietic stroma damage by irradiation on the efficiency of engraftment of intravenously transplanted stem cells. It was previously demonstrated that in normal syngenic mice, all intravenously transplanted donor stem cells, present in the bone marrow, compete equally with those of the host. In this study, we comprehensively compared the blood cell production derived from transplanted donor stem cells with that from the host stem cells surviving various doses of submyeloablative irradiation. We compared the partial chimerism resulting from transplantation with theoretical estimates that assumed transplantation efficiencies ranging from 100% to 20%. The highest level of consensus between the experimental and the theoretical results was 100% for homing and engraftment (ie, the utilization of all transplanted stem cells). These results point to a very potent mechanism through which intravenously administered hematopoietic stem cells are captured from circulation, engraft in the hematopoietic tissue, and contribute to blood cell production in irradiated recipients. The damage done to hematopoietic stroma and to the trabecular bone by submyeloablative doses of ionizing radiation does not negatively affect the homing and engraftment mechanisms of intravenously transplanted hematopoietic progenitor and stem cells. (C) 2013 American Society for Blood and Marrow Transplantation.
dcterms:title
All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice
skos:prefLabel
All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice
skos:notation
RIV/00216208:11110/13:10189436!RIV14-MSM-11110___
n14:predkladatel
n15:orjk%3A11110
n3:aktivita
n16:Z n16:S n16:P n16:I
n3:aktivity
I, P(LC06044), S, Z(MSM0021620806)
n3:cisloPeriodika
5
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n8:3244946 n8:9585168 n8:4977483 n8:8439664 n8:8486085
n3:druhVysledku
n6:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
60117
n3:idVysledku
RIV/00216208:11110/13:10189436
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Submyeloablative irradiation; Engraftment efficiency; Bone marrow transplantation; Hematopoietic stem cells
n3:klicoveSlovo
n4:Engraftment%20efficiency n4:Submyeloablative%20irradiation n4:Hematopoietic%20stem%20cells n4:Bone%20marrow%20transplantation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[54C62AD44AC0]
n3:nazevZdroje
Biology of Blood and Marrow Transplantation
n3:obor
n20:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n22:LC06044
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
19
n3:tvurceVysledku
Linhartová, Jana Savvulidi, Filipp Geirgievich Forgáčová, Katarína Nečas, Emanuel Šefc, Luděk
n3:wos
000318132500006
n3:zamer
n17:MSM0021620806
s:issn
1083-8791
s:numberOfPages
7
n12:doi
10.1016/j.bbmt.2013.02.012
n5:organizacniJednotka
11110