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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10188972%21RIV14-MSM-11110___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.envres.2012.09.008
dcterms:description
Background: Indoor air pollution from solid fuels is a potentially important risk factor for cancer, yet data on cancers from organs other than the lung are scarce. We investigated if indoor air pollution from coal and wood are risk factors for additional cancers, particularly that of the upper aerodigestive tract (oral cavity, larynx, pharynx and esophagus) in the high-risk areas of Central and Eastern Europe. Methods: We used data from multi-center hospital-based case-control study of 1065 histologically confirmed upper aerodigestive tract cancer cases and 1346 controls. Standardized questionnaires were used to collect information on residential fuel use for cooking and heating. Using unconditional logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for upper aerodigestive tract cancer risk after adjusting for potential confounders. Results: Lifelong wood use was associated with pharyngeal and esophageal (OR 4.05, 95% CI: 1.30-12.68 and OR 2.71, 95% CI: 1.21-6.10, respectively). We observed an exposure-response relationship between duration of wood use and risk of pharyngeal cancer among those who had never used coal (P-trend = 0.04), ruling out the possibility of residual confounding by coal. Similarly, we observed an increased risk of laryngeal cancers and head & neck cancers among those who always used coal, with a noted exposure-response relationship (P-trend < 0.01). Conclusions: Our results suggest a possible role of indoor air pollution from solid fuel use in head and neck carcinogenesis in the high risk area of Central and Eastern Europe. Background: Indoor air pollution from solid fuels is a potentially important risk factor for cancer, yet data on cancers from organs other than the lung are scarce. We investigated if indoor air pollution from coal and wood are risk factors for additional cancers, particularly that of the upper aerodigestive tract (oral cavity, larynx, pharynx and esophagus) in the high-risk areas of Central and Eastern Europe. Methods: We used data from multi-center hospital-based case-control study of 1065 histologically confirmed upper aerodigestive tract cancer cases and 1346 controls. Standardized questionnaires were used to collect information on residential fuel use for cooking and heating. Using unconditional logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for upper aerodigestive tract cancer risk after adjusting for potential confounders. Results: Lifelong wood use was associated with pharyngeal and esophageal (OR 4.05, 95% CI: 1.30-12.68 and OR 2.71, 95% CI: 1.21-6.10, respectively). We observed an exposure-response relationship between duration of wood use and risk of pharyngeal cancer among those who had never used coal (P-trend = 0.04), ruling out the possibility of residual confounding by coal. Similarly, we observed an increased risk of laryngeal cancers and head & neck cancers among those who always used coal, with a noted exposure-response relationship (P-trend < 0.01). Conclusions: Our results suggest a possible role of indoor air pollution from solid fuel use in head and neck carcinogenesis in the high risk area of Central and Eastern Europe.
dcterms:title
Indoor air pollution from solid fuels and risk of upper aerodigestive tract cancers in Central and Eastern Europe Indoor air pollution from solid fuels and risk of upper aerodigestive tract cancers in Central and Eastern Europe
skos:prefLabel
Indoor air pollution from solid fuels and risk of upper aerodigestive tract cancers in Central and Eastern Europe Indoor air pollution from solid fuels and risk of upper aerodigestive tract cancers in Central and Eastern Europe
skos:notation
RIV/00216208:11110/13:10188972!RIV14-MSM-11110___
n11:predkladatel
n17:orjk%3A11110
n3:aktivita
n8:R n8:N
n3:aktivity
N, R
n3:cisloPeriodika
JAN
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n4:8807574
n3:druhVysledku
n10:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
79573
n3:idVysledku
RIV/00216208:11110/13:10188972
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Cancer; Dung; Agricultural waste; Coal; Wood; Indoor air pollution
n3:klicoveSlovo
n6:Cancer n6:Dung n6:Agricultural%20waste n6:Coal n6:Indoor%20air%20pollution n6:Wood
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5032C7EA359F]
n3:nazevZdroje
Environmental Research
n3:obor
n12:FM
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
120
n3:tvurceVysledku
Mates, D. Brennan, P. Szeszenia-Dabrowska, N. Fabianova, E. Boffetta, P. Janout, V. Rudnai, P. Sapkota, A. Holcátová, Ivana Hashibe, M. Zaridze, D.
n3:wos
000313606400012
s:issn
0013-9351
s:numberOfPages
6
n9:doi
10.1016/j.envres.2012.09.008
n20:organizacniJednotka
11110