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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A10174139%21RIV14-MSM-11110___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1517/14728222.2013.750651
dcterms:description
Introduction: One route of translating the information encoded in the glycan chains of cellular glycoconjugates into physiological effects is via receptor (lectin) binding. A family of endogenous lectins, sharing folding, a distinct sequence signature and affinity for beta-galactosides (thus termed galectins), does so effectively in a context-dependent manner. Areas covered: An overview is given on the multifunctional nature of galectins, with emphasis on galectin-1. The broad range of functions includes vital processes such as adhesion via glycan bridging, glycoconjugate transport or triggering signaling relevant, for example, for growth regulation. Besides distinct glycoconjugates, this lectin can also interact with certain proteins so that it can target counterreceptors at all sites of location, that is, in the cytoplasm and/or nucleus, at both sides of the membrane or extracellularly. Approaches to strategically exploit galectin activities with therapeutic intentions are outlined. Expert opinion: The wide versatility of sugar coding and the multifunctionality of galectin-1 explain why considering to turn the protein into a therapeutic target is an ambitious aim. Natural pathways shaped by physiologic master regulators (e.g., the tumor suppressor p16(INK4a)) are suggested to teach inspiring lessons as to how the lectin might be recruited to clinical service. Introduction: One route of translating the information encoded in the glycan chains of cellular glycoconjugates into physiological effects is via receptor (lectin) binding. A family of endogenous lectins, sharing folding, a distinct sequence signature and affinity for beta-galactosides (thus termed galectins), does so effectively in a context-dependent manner. Areas covered: An overview is given on the multifunctional nature of galectins, with emphasis on galectin-1. The broad range of functions includes vital processes such as adhesion via glycan bridging, glycoconjugate transport or triggering signaling relevant, for example, for growth regulation. Besides distinct glycoconjugates, this lectin can also interact with certain proteins so that it can target counterreceptors at all sites of location, that is, in the cytoplasm and/or nucleus, at both sides of the membrane or extracellularly. Approaches to strategically exploit galectin activities with therapeutic intentions are outlined. Expert opinion: The wide versatility of sugar coding and the multifunctionality of galectin-1 explain why considering to turn the protein into a therapeutic target is an ambitious aim. Natural pathways shaped by physiologic master regulators (e.g., the tumor suppressor p16(INK4a)) are suggested to teach inspiring lessons as to how the lectin might be recruited to clinical service.
dcterms:title
Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target
skos:prefLabel
Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target
skos:notation
RIV/00216208:11110/13:10174139!RIV14-MSM-11110___
n12:predkladatel
n16:orjk%3A11110
n4:aktivita
n19:I
n4:aktivity
I
n4:cisloPeriodika
4
n4:dodaniDat
n7:2014
n4:domaciTvurceVysledku
n11:3221105
n4:druhVysledku
n18:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
66875
n4:idVysledku
RIV/00216208:11110/13:10174139
n4:jazykVysledku
n9:eng
n4:klicovaSlova
tumor suppressor; stroma; sialylation; lectin; glycosylation; apoptosis
n4:klicoveSlovo
n5:lectin n5:tumor%20suppressor n5:sialylation n5:stroma n5:apoptosis n5:glycosylation
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6DF6B79FDB3E]
n4:nazevZdroje
Expert Opinion on Therapeutic Targets
n4:obor
n17:CE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n7:2013
n4:svazekPeriodika
17
n4:tvurceVysledku
Andre, Sabine Gabius, Hans-Joachim Smetana, Karel Kaltner, Herbert Kopitz, Juergen
n4:wos
000316127600005
s:issn
1472-8222
s:numberOfPages
14
n13:doi
10.1517/14728222.2013.750651
n14:organizacniJednotka
11110