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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F13%3A00011958%21RIV14-MV0-11110___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1007/s00213-012-2797-7
dcterms:description
Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence was observed. Amphetamine mainly induced an increase in EEG power and coherence in theta and alpha bands. Increases in the theta and alpha power and coherence in 2C-B and amphetamine were temporally linked to an increase in locomotor activity and DA levels in NAc. 2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed. Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence was observed. Amphetamine mainly induced an increase in EEG power and coherence in theta and alpha bands. Increases in the theta and alpha power and coherence in 2C-B and amphetamine were temporally linked to an increase in locomotor activity and DA levels in NAc. 2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed.
dcterms:title
Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats
skos:prefLabel
Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats
skos:notation
RIV/00216208:11110/13:00011958!RIV14-MV0-11110___
n15:predkladatel
n16:orjk%3A11110
n4:aktivita
n12:V n12:Z n12:P
n4:aktivity
P(1M0517), P(NS10374), P(NS10375), P(NT13843), P(NT13897), P(VG20122015075), P(VG20122015080), V, Z(AV0Z50110509), Z(MZ0PCP2005)
n4:cisloPeriodika
1
n4:dodaniDat
n9:2014
n4:domaciTvurceVysledku
n13:6791670
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n21:predkladatel
n4:idSjednocenehoVysledku
63025
n4:idVysledku
RIV/00216208:11110/13:00011958
n4:jazykVysledku
n18:eng
n4:klicovaSlova
Rats; EEG coherence; EEG power spectra; Microdialysis; Behavior; Nucleus accumbens; Dopamine; Serotonin; Amphetamine; 4-Bromo-2,5-dimethoxyphenethylamine(2C-B)
n4:klicoveSlovo
n6:EEG%20coherence n6:Microdialysis n6:Dopamine n6:5-dimethoxyphenethylamine%282C-B%29 n6:Behavior n6:EEG%20power%20spectra n6:4-Bromo-2 n6:Amphetamine n6:Rats n6:Nucleus%20accumbens n6:Serotonin
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[102BA4D31E56]
n4:nazevZdroje
Psychopharmacology
n4:obor
n8:FH
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
15
n4:projekt
n11:1M0517 n11:VG20122015075 n11:VG20122015080 n11:NT13843 n11:NT13897 n11:NS10374 n11:NS10375
n4:rokUplatneniVysledku
n9:2013
n4:svazekPeriodika
225
n4:tvurceVysledku
Syslová, Kamila Brunovský, Martin Kubešová, Anna Rambousek, Lukáš Horáček, Jiří Balíková, Marie Kačer, Petr Puskarčíková, Jana Tylš, Filip Bubeníková-Valešová, Věra Páleníček, Tomáš Höschl, Cyril Zach, Petr Fujáková, Michaela Gorman, Ingmar
n4:wos
000313163900007
n4:zamer
n7:MZ0PCP2005 n7:AV0Z50110509
s:issn
0033-3158
s:numberOfPages
19
n22:doi
10.1007/s00213-012-2797-7
n20:organizacniJednotka
11110