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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F12%3A12960%21RIV13-MSM-11110___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://ccforum.com/content/16/3/133
dcterms:description
Heparin-binding protein (HBP), also known as azurocidin, has multiple functions in the inflammatory process, especially during severe infections. Beside its antimicrobial properties, HBP may induce vascular leakage leading to extravascular efflux, which is an important pathophysiologic event in the development of septic shock. Not surprisingly, high HBP plasma levels are found in severe sepsis patients and in septic shock patients as well as in serious infections associated with endothelial damage. In the present issue of Critical Care, Linder and colleagues demonstrate new aspects of HBP daily monitoring in ICU patients. The authors observed that high HBP plasma levels are associated with an increased mortality rate in both septic and nonseptic critically ill patients, indicating that HBP may be a reliable prognostic biomarker. However, there are some limitations hindering rapid translation of these interesting findings into the daily routine. First, the group of nonseptic critically ill patients (n = 28) enrolled in the study was rather small as compared with the septic group (n = 151). Moreover, 50% of nonseptic patients developed infection while hospitalized in the ICU, and to classify them as truly nonseptic patients is problematic. Second, there is a lack of a routine diagnostic method for HBP analysis. Nevertheless, if the results of the present study are validated in large clinical trials in different ICU populations and cost-effectiveness data become available, the serial HBP measurements will have a promising future. Heparin-binding protein (HBP), also known as azurocidin, has multiple functions in the inflammatory process, especially during severe infections. Beside its antimicrobial properties, HBP may induce vascular leakage leading to extravascular efflux, which is an important pathophysiologic event in the development of septic shock. Not surprisingly, high HBP plasma levels are found in severe sepsis patients and in septic shock patients as well as in serious infections associated with endothelial damage. In the present issue of Critical Care, Linder and colleagues demonstrate new aspects of HBP daily monitoring in ICU patients. The authors observed that high HBP plasma levels are associated with an increased mortality rate in both septic and nonseptic critically ill patients, indicating that HBP may be a reliable prognostic biomarker. However, there are some limitations hindering rapid translation of these interesting findings into the daily routine. First, the group of nonseptic critically ill patients (n = 28) enrolled in the study was rather small as compared with the septic group (n = 151). Moreover, 50% of nonseptic patients developed infection while hospitalized in the ICU, and to classify them as truly nonseptic patients is problematic. Second, there is a lack of a routine diagnostic method for HBP analysis. Nevertheless, if the results of the present study are validated in large clinical trials in different ICU populations and cost-effectiveness data become available, the serial HBP measurements will have a promising future.
dcterms:title
Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock? Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock?
skos:prefLabel
Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock? Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock?
skos:notation
RIV/00216208:11110/12:12960!RIV13-MSM-11110___
n16:predkladatel
n17:orjk%3A11110
n3:aktivita
n10:Z
n3:aktivity
Z(MSM0021620806)
n3:cisloPeriodika
3
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n11:3039145 n11:5649617
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
167760
n3:idVysledku
RIV/00216208:11110/12:12960
n3:jazykVysledku
n18:eng
n3:klicovaSlova
sepsis, C-reactive protein; heparin binding protein
n3:klicoveSlovo
n12:C-reactive%20protein n12:heparin%20binding%20protein n12:sepsis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[73D4503DEFF4]
n3:nazevZdroje
Critical Care
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
16
n3:tvurceVysledku
Beran, Ondřej Holub, Michal
n3:wos
000313197500053
n3:zamer
n20:MSM0021620806
s:issn
1466-609X
s:numberOfPages
2
n9:organizacniJednotka
11110