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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F12%3A12847%21RIV13-MZ0-11110___
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
https://www.novapublishers.com/catalog/product_info.php?products_id=37164
dcterms:description
SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression. SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression.
dcterms:title
MITF meets chromatin in melanoma MITF meets chromatin in melanoma
skos:prefLabel
MITF meets chromatin in melanoma MITF meets chromatin in melanoma
skos:notation
RIV/00216208:11110/12:12847!RIV13-MZ0-11110___
n4:predkladatel
n12:orjk%3A11110
n3:aktivita
n16:P
n3:aktivity
P(NT11229)
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n13:8244618 n13:1315145
n3:druhVysledku
n19:C
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
150734
n3:idVysledku
RIV/00216208:11110/12:12847
n3:jazykVysledku
n21:eng
n3:klicovaSlova
SWI/SNF; MITF; melanoma; Brg1; Brm; INI1
n3:klicoveSlovo
n5:Brg1 n5:Brm n5:SWI%2FSNF n5:MITF n5:INI1 n5:melanoma
n3:kontrolniKodProRIV
[FE6E7FE5A5CE]
n3:mistoVydani
New York
n3:nazevEdiceCisloSvazku
Cell Biology Research Progress
n3:nazevZdroje
New Developments in Chromatin Research
n3:obor
n7:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetStranKnihy
247
n3:pocetTvurcuVysledku
2
n3:projekt
n22:NT11229
n3:rokUplatneniVysledku
n10:2012
n3:tvurceVysledku
Vachtenheim, Jiří Ondrušová, Ľubica
s:numberOfPages
18
n20:hasPublisher
Nova Science Publishers
n8:isbn
978-1-62081-816-9
n15:organizacniJednotka
11110