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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F11%3A9165%21RIV12-MZ0-11110___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1159/000329291
dcterms:description
Background: The calcium-binding protein S100A12 (EN-RAGE) causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with decreased renal function. Methods: The studied group consisted of 46 patients with various degrees of chronic renal insufficiency (CHRI), 31 long-term hemodialysis (HD) patients and 24 healthy controls. S100A12 and soluble RAGE were assessed immunochemically (ELISA), and routine biochemical parameters were measured. Results: S100A12 levels were not different in CHRI (166 +/- 140 ng/ml) and HD patients (127 +/- 101 ng/ml) compared to controls (126 +/- 106 ng/ml; p = 0.20, n.s.). In CHRI patients, S100A12 correlated with C-reactive protein (CRP) levels, orosomucoid, and inversely with alpha(2)-macroglobulin. In HD patients, S100A12 correlated with age, CRP, orosomucoid, fibrinogen and leukocyte levels. In multivariate regression analysis after adjustment for age, S100A12 levels remained correlated with: orosomucoid in CHRI patients; CRP, leukocytes, fibrinogen and negatively with sRAGE in HD patients; and leukocytes in controls. Conclusions: Although S100A12 levels were not elevated in patients with decreased kidney function, a relation to markers of inflammation was found. Further studies are required to demonstrate the significance of S100A12 in patients with decreased renal function. Background: The calcium-binding protein S100A12 (EN-RAGE) causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with decreased renal function. Methods: The studied group consisted of 46 patients with various degrees of chronic renal insufficiency (CHRI), 31 long-term hemodialysis (HD) patients and 24 healthy controls. S100A12 and soluble RAGE were assessed immunochemically (ELISA), and routine biochemical parameters were measured. Results: S100A12 levels were not different in CHRI (166 +/- 140 ng/ml) and HD patients (127 +/- 101 ng/ml) compared to controls (126 +/- 106 ng/ml; p = 0.20, n.s.). In CHRI patients, S100A12 correlated with C-reactive protein (CRP) levels, orosomucoid, and inversely with alpha(2)-macroglobulin. In HD patients, S100A12 correlated with age, CRP, orosomucoid, fibrinogen and leukocyte levels. In multivariate regression analysis after adjustment for age, S100A12 levels remained correlated with: orosomucoid in CHRI patients; CRP, leukocytes, fibrinogen and negatively with sRAGE in HD patients; and leukocytes in controls. Conclusions: Although S100A12 levels were not elevated in patients with decreased kidney function, a relation to markers of inflammation was found. Further studies are required to demonstrate the significance of S100A12 in patients with decreased renal function.
dcterms:title
Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease
skos:prefLabel
Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease
skos:notation
RIV/00216208:11110/11:9165!RIV12-MZ0-11110___
n14:predkladatel
n15:orjk%3A11110
n4:aktivita
n5:V n5:S n5:P
n4:aktivity
P(NS10043), S, V
n4:cisloPeriodika
6
n4:dodaniDat
n18:2012
n4:domaciTvurceVysledku
n6:8684731 n6:8705097 n6:6377165 n6:5909627
n4:druhVysledku
n9:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
228975
n4:idVysledku
RIV/00216208:11110/11:9165
n4:jazykVysledku
n12:eng
n4:klicovaSlova
Calcium; binding protein, chronic kidney disease; EN - RAGE; hemodialysis; inflammation; protein; S; 00A12; sRAGE
n4:klicoveSlovo
n8:inflammation n8:sRAGE n8:S n8:chronic%20kidney%20disease n8:binding%20protein n8:00A12 n8:hemodialysis n8:Calcium n8:EN n8:protein
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[D41FFA3C6EDF]
n4:nazevZdroje
Kidney and Blood Pressure Research
n4:obor
n11:FE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n20:NS10043
n4:rokUplatneniVysledku
n18:2011
n4:svazekPeriodika
34
n4:tvurceVysledku
Kalousová, Marta Kříha, Vítězslav Zakiyanov, Oskar Zima, Tomáš Tesař, Vladimír
n4:wos
000297128400011
s:issn
1420-4096
s:numberOfPages
8
n17:organizacniJednotka
11110