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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F11%3A10852%21RIV12-GA0-11110___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://node.nel.edu/?node_id=12266
dcterms:description
Within the last two decades of studies in the ever-expanding field of GPCR signaling, challenging insights were adopted. Growing evidence now asists the shift from classical linear model of signaling towards a considerably complex network of signaling pathways with many shared proteins and cross-talks. Considering the extensive and intriguing network of pathways activated by these receptors, it is apparent that multi-level system of regulation must exist to rigorously modulate the amplitude, duration and spatial aspects of the GPCR signaling. This review summarizes the principal mechanisms of GPCR regulation and gives the overview of recent advances in this field of research. Within the last two decades of studies in the ever-expanding field of GPCR signaling, challenging insights were adopted. Growing evidence now asists the shift from classical linear model of signaling towards a considerably complex network of signaling pathways with many shared proteins and cross-talks. Considering the extensive and intriguing network of pathways activated by these receptors, it is apparent that multi-level system of regulation must exist to rigorously modulate the amplitude, duration and spatial aspects of the GPCR signaling. This review summarizes the principal mechanisms of GPCR regulation and gives the overview of recent advances in this field of research.
dcterms:title
Mechanisms of G protein-coupled receptors regulation Mechanisms of G protein-coupled receptors regulation
skos:prefLabel
Mechanisms of G protein-coupled receptors regulation Mechanisms of G protein-coupled receptors regulation
skos:notation
RIV/00216208:11110/11:10852!RIV12-GA0-11110___
n6:predkladatel
n14:orjk%3A11110
n4:aktivita
n8:P
n4:aktivity
P(GA309/09/0406)
n4:cisloPeriodika
5
n4:dodaniDat
n16:2012
n4:domaciTvurceVysledku
n17:1666495
n4:druhVysledku
n19:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
211295
n4:idVysledku
RIV/00216208:11110/11:10852
n4:jazykVysledku
n11:eng
n4:klicovaSlova
GPCR signaling; complex network; pathways
n4:klicoveSlovo
n9:GPCR%20signaling n9:complex%20network n9:pathways
n4:kodStatuVydavatele
SE - Švédské království
n4:kontrolniKodProRIV
[1E09B0715833]
n4:nazevZdroje
Neuroendocrinology Letters
n4:obor
n20:ED
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
2
n4:projekt
n13:GA309%2F09%2F0406
n4:rokUplatneniVysledku
n16:2011
n4:svazekPeriodika
32
n4:tvurceVysledku
Tománková, H. Mysliveček, Jaromír
n4:wos
000300543900004
s:issn
0172-780X
s:numberOfPages
9
n18:organizacniJednotka
11110