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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F10%3A6854%21RIV11-GA0-11110___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Mammalian CcO (cytochrome c oxidase) is a complex composed of 13 different structural subunits encoded by both the mitochondrial and nuclear genomes. Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and an altered pattern of respiratory supercomplexes. An analysis of the patterns of CcO subcomplexes found in both knockdowns and cells overexpressing epitope-tagged Cox6a, Cox7a and Cox7b identified a novel CcO assembly intermediate, identified the entry points of three late-assembled subunits and demonstrated the interdependence of Cox4 and Cox5a assembly. The ectopic expression of the heart/muscle-specific isoform of the Cox6 subunit (COX6A2) resulted in restoration of both CcO holoenzyme and activity in COX6A1-knockdown cells contrary to the unaltered levels of COX6A2 mRNA in these cells, suggesting the existence of a fixed expression programme. Mammalian CcO (cytochrome c oxidase) is a complex composed of 13 different structural subunits encoded by both the mitochondrial and nuclear genomes. Knockdown of Cox4, Cox5a and Cox6a resulted in reduced CcO activity, diminished affinity of the residual enzyme for oxygen, decreased holoCcO and CcO dimer levels, increased accumulation of CcO subcomplexes and an altered pattern of respiratory supercomplexes. An analysis of the patterns of CcO subcomplexes found in both knockdowns and cells overexpressing epitope-tagged Cox6a, Cox7a and Cox7b identified a novel CcO assembly intermediate, identified the entry points of three late-assembled subunits and demonstrated the interdependence of Cox4 and Cox5a assembly. The ectopic expression of the heart/muscle-specific isoform of the Cox6 subunit (COX6A2) resulted in restoration of both CcO holoenzyme and activity in COX6A1-knockdown cells contrary to the unaltered levels of COX6A2 mRNA in these cells, suggesting the existence of a fixed expression programme.
dcterms:title
Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
skos:prefLabel
Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
skos:notation
RIV/00216208:11110/10:6854!RIV11-GA0-11110___
n3:aktivita
n4:P n4:Z
n3:aktivity
P(1M0520), P(GA303/07/0781), P(NS10581), Z(MSM0021620806)
n3:cisloPeriodika
part 3
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n12:6479200 n12:3610993 n12:6270875 n12:5718201 n12:5315263 n12:7975694
n3:druhVysledku
n5:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
275435
n3:idVysledku
RIV/00216208:11110/10:6854
n3:jazykVysledku
n19:eng
n3:klicovaSlova
cytochrome c oxidase; protein assembly; respiratory supercomplex; RNA interference (RNAi)
n3:klicoveSlovo
n14:RNA%20interference%20%28RNAi%29 n14:cytochrome%20c%20oxidase n14:protein%20assembly n14:respiratory%20supercomplex
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[96A0339E57FF]
n3:nazevZdroje
Biochemical Journal
n3:obor
n18:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n17:1M0520 n17:GA303%2F07%2F0781 n17:NS10581
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
428
n3:tvurceVysledku
Stibůrek, Lukáš Hansíková, Hana Wenchich, László Fornůsková, Daniela Vinšová, Kamila Zeman, Jiří
n3:wos
000278914400005
n3:zamer
n6:MSM0021620806
s:issn
0264-6021
s:numberOfPages
12
n13:organizacniJednotka
11110