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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F10%3A6825%21RIV11-MZ0-11110___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
The mitochondrial biogenesis and adequate energy production are important for fetal growth and early postnatal adaptation. The aim of the study was to characterize mitochondrial DNA (mtDNA) content and expression patterns of POLG, TFAM, NRF1,NRF2 and PGC1 family of regulated coactivators (PGC1A, PGC1B and PRC), COX4 and MTCO2 in human fetal tissues during gestation. Moreover enzyme activities of COX and CS and protein levels of cytochrome c oxidase (COX) subunits were analysed. DNA, RNA and proteins were isolated from 26 pairs of fetal liver and muscle samples between 13th and 28th week of gestation. This work offers a broad view on the differences in expression of POLG, TFAM, NRF2 genes and family PGC1 coactivators found between the fetal tissues. The significant tissue-specific changes in expression of selected COX subunits on mRNA level were observed. The considerable differences in enzyme activities of COX and CS are demonstrated between fetal and postnatal phase. In conclusion our study indicates The mitochondrial biogenesis and adequate energy production are important for fetal growth and early postnatal adaptation. The aim of the study was to characterize mitochondrial DNA (mtDNA) content and expression patterns of POLG, TFAM, NRF1,NRF2 and PGC1 family of regulated coactivators (PGC1A, PGC1B and PRC), COX4 and MTCO2 in human fetal tissues during gestation. Moreover enzyme activities of COX and CS and protein levels of cytochrome c oxidase (COX) subunits were analysed. DNA, RNA and proteins were isolated from 26 pairs of fetal liver and muscle samples between 13th and 28th week of gestation. This work offers a broad view on the differences in expression of POLG, TFAM, NRF2 genes and family PGC1 coactivators found between the fetal tissues. The significant tissue-specific changes in expression of selected COX subunits on mRNA level were observed. The considerable differences in enzyme activities of COX and CS are demonstrated between fetal and postnatal phase. In conclusion our study indicates
dcterms:title
Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development
skos:prefLabel
Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development
skos:notation
RIV/00216208:11110/10:6825!RIV11-MZ0-11110___
n3:aktivita
n15:Z n15:P
n3:aktivity
P(1M0520), P(NR9410), Z(MSM0021620806)
n3:cisloPeriodika
4
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n4:1016717 n4:6270875 n4:4540344 n4:1045261 n4:4768817 n4:7786301 n4:5315263 n4:7975694
n3:druhVysledku
n18:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
271602
n3:idVysledku
RIV/00216208:11110/10:6825
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Mitochondrial biogenesis; mtDNA; Fetal development; POLG; TFAM; NRF
n3:klicoveSlovo
n12:Mitochondrial%20biogenesis n12:Fetal%20development n12:POLG n12:NRF n12:mtDNA n12:TFAM
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7DBB217E7B4E]
n3:nazevZdroje
Mitochondrion
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:projekt
n14:NR9410 n14:1M0520
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
10
n3:tvurceVysledku
Havlíčková, Vendula Hůlková, Martina Hájková, Zuzana Hansíková, Hana Vinšová, Kamila Magner, Martin Honzík, Tomáš Zeman, Jiří Tesařová, Markéta
n3:wos
000278262600003
n3:zamer
n5:MSM0021620806
s:issn
1567-7249
s:numberOfPages
9
n19:organizacniJednotka
11110