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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F09%3A5407%21RIV10-MSM-11110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Liver transplantation (LT) in immune-suppressed human immunodeficiency virus(HIV) and hepatitis C virus (HCV) coinfected patients is feasible but raises questions regarding the severity of HCV recurrence on the liver graft and preservation of immune function. We investigated whether LT is deleterious to the immune system. Fourteen HIV-HCV coinfected patients (HIV viral load [VL] <50 copies/ml; median CD4 count of 276/mm(3) pretransplantation) were grafted for HCV-cirrhosis and followed over 2 years. HCV and HIV VLs and degree of acute and chronic hepatitis were monitored. Peripheral blood T-cell phenotypes and interferon-gamma (IFN-gamma) immune responses against opportunistic pathogens, HCV, and HIV-1 p24 were evaluated. The study demonstrates that LT in HIV-HCV coinfected patients is not deleterious to the immune system and does not alter immune responses directed against HCV, HIV, or opportunistic pathogens. Liver transplantation (LT) in immune-suppressed human immunodeficiency virus(HIV) and hepatitis C virus (HCV) coinfected patients is feasible but raises questions regarding the severity of HCV recurrence on the liver graft and preservation of immune function. We investigated whether LT is deleterious to the immune system. Fourteen HIV-HCV coinfected patients (HIV viral load [VL] <50 copies/ml; median CD4 count of 276/mm(3) pretransplantation) were grafted for HCV-cirrhosis and followed over 2 years. HCV and HIV VLs and degree of acute and chronic hepatitis were monitored. Peripheral blood T-cell phenotypes and interferon-gamma (IFN-gamma) immune responses against opportunistic pathogens, HCV, and HIV-1 p24 were evaluated. The study demonstrates that LT in HIV-HCV coinfected patients is not deleterious to the immune system and does not alter immune responses directed against HCV, HIV, or opportunistic pathogens.
dcterms:title
Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV-HCV coinfected patients (ANRS-HC08 %22THEVIC%22 trial) Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV-HCV coinfected patients (ANRS-HC08 %22THEVIC%22 trial)
skos:prefLabel
Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV-HCV coinfected patients (ANRS-HC08 %22THEVIC%22 trial) Preservation of immune function and anti-hepatitis C virus (HCV) immune responses after liver transplantation in HIV-HCV coinfected patients (ANRS-HC08 %22THEVIC%22 trial)
skos:notation
RIV/00216208:11110/09:5407!RIV10-MSM-11110___
n3:aktivita
n18:Z
n3:aktivity
Z(MSM0021620806)
n3:cisloPeriodika
6
n3:dodaniDat
n7:2010
n3:domaciTvurceVysledku
n11:3039145
n3:druhVysledku
n12:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
335778
n3:idVysledku
RIV/00216208:11110/09:5407
n3:jazykVysledku
n4:eng
n3:klicovaSlova
HIV-HCV coinfection; HCV recurrence; Anti-HCV immune response; Anti-HCV therapy; Liver transplantation
n3:klicoveSlovo
n8:Liver%20transplantation n8:Anti-HCV%20immune%20response n8:Anti-HCV%20therapy n8:HIV-HCV%20coinfection n8:HCV%20recurrence
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E50AC49AA262]
n3:nazevZdroje
Journal of Hepatology
n3:obor
n15:FN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
13
n3:rokUplatneniVysledku
n7:2009
n3:svazekPeriodika
51
n3:tvurceVysledku
Roque-Afonso, Anne-Marie Samri, Assia Beran, Ondřej
n3:wos
000272862200006
n3:zamer
n10:MSM0021620806
s:issn
0168-8278
s:numberOfPages
10
n17:organizacniJednotka
11110