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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F09%3A4660%21RIV10-MSM-11110___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies’ positivity. We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH was determined to be 0.06–3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies’ positivity. We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH was determined to be 0.06–3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive.
dcterms:title
Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy
skos:prefLabel
Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy
skos:notation
RIV/00216208:11110/09:4660!RIV10-MSM-11110___
n3:aktivita
n12:Z
n3:aktivity
Z(MSM0021620807)
n3:cisloPeriodika
5
n3:dodaniDat
n15:2010
n3:domaciTvurceVysledku
n10:9358668 n10:9234322 n10:8705097
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
338494
n3:idVysledku
RIV/00216208:11110/09:4660
n3:jazykVysledku
n18:eng
n3:klicovaSlova
thyroid dysfunction; pregnancy; reference interval; TSH; FT4; anti-TPO
n3:klicoveSlovo
n6:reference%20interval n6:thyroid%20dysfunction n6:pregnancy n6:anti-TPO n6:FT4 n6:TSH
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8E82979A4F2F]
n3:nazevZdroje
European Journal of Endocrinology
n3:obor
n5:FB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n15:2009
n3:svazekPeriodika
160
n3:tvurceVysledku
Zima, Tomáš Springer, Drahomíra Límanová, Zdeňka
n3:wos
000272934500010
n3:zamer
n9:MSM0021620807
s:issn
0804-4643
s:numberOfPages
7
n13:organizacniJednotka
11110