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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F09%3A3832%21RIV10-MZ0-11110___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The aim of this work was to study the effects of resveratrol (RES) as compared to silymarin (SM) pretreatments on tert-butylhydroperoxide (tBH) induced apoptotic/necrotic markers in hepatocytes. Hepatocyte in cultures (48 h) and in perifused immobilized agarose threads (5 h) were used as cellular systems. Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining. Hepatocyte viability and functionality were evaluated by ALT and urea synthesis. Nitric oxide (NO) and carbon monoxide involvements were also examined. Resveratrol and silymarin reduced tBH-induced hepatocyte toxic effects in short term experiments (5 h) as measured by a significant reduction in ALT and NO increase produced by tBH. Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments. The aim of this work was to study the effects of resveratrol (RES) as compared to silymarin (SM) pretreatments on tert-butylhydroperoxide (tBH) induced apoptotic/necrotic markers in hepatocytes. Hepatocyte in cultures (48 h) and in perifused immobilized agarose threads (5 h) were used as cellular systems. Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining. Hepatocyte viability and functionality were evaluated by ALT and urea synthesis. Nitric oxide (NO) and carbon monoxide involvements were also examined. Resveratrol and silymarin reduced tBH-induced hepatocyte toxic effects in short term experiments (5 h) as measured by a significant reduction in ALT and NO increase produced by tBH. Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments.
dcterms:title
Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1 Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1
skos:prefLabel
Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1 Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1
skos:notation
RIV/00216208:11110/09:3832!RIV10-MZ0-11110___
n5:aktivita
n16:Z n16:P
n5:aktivity
P(1M0508), P(GA305/07/0061), P(NR9379), Z(AV0Z50390512), Z(MSM0021620807)
n5:cisloPeriodika
1
n5:dodaniDat
n14:2010
n5:domaciTvurceVysledku
n8:4693728 n8:3596850 n8:1295535 n8:4231406 n8:8459843
n5:druhVysledku
n18:J
n5:duvernostUdaju
n13:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
312434
n5:idVysledku
RIV/00216208:11110/09:3832
n5:jazykVysledku
n6:eng
n5:klicovaSlova
Resveratrol; tert-butylhydroperoxide; hepatocyte; Nitric oxide; Hemoxygenase-1
n5:klicoveSlovo
n10:tert-butylhydroperoxide n10:Nitric%20oxide n10:Resveratrol n10:Hemoxygenase-1 n10:hepatocyte
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[146A985837EC]
n5:nazevZdroje
Nitric Oxide
n5:obor
n17:EA
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
7
n5:projekt
n9:NR9379 n9:GA305%2F07%2F0061 n9:1M0508
n5:rokUplatneniVysledku
n14:2009
n5:svazekPeriodika
20
n5:tvurceVysledku
Zídek, Zdeněk Černý, Dalibor Kutinová-Canová, Nikolina Hořínek, Aleš Martínek, Jindřich Farghali, Hassan Kmoníčková, Eva
n5:wos
000261231600001
n5:zamer
n12:MSM0021620807 n12:AV0Z50390512
s:issn
1089-8603
s:numberOfPages
8
n15:organizacniJednotka
11110