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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F09%3A3716%21RIV10-MSM-11110___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Background: Galectin-1 has been found to modulate lymphocyte invasion in inflammation and to be involved in angiogenesis in models, thus prompting examination of its clinical relevance in laryngeal cancer. Patients and Methods: Immunohistochemical processing of tissue sections (n=53) from patients with stage I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was combined with quantitative morphometric analysis. Results: Lectin presence in the tumor and endothelial cells was positively correlated, while a negative relationship to the number of CD45-positive lymphocytes was demonstrated. No association was seen with the extent of neovascularization. The mean optical density (MOD) of lectin-dependent staining in the tumor stroma was significantly, increased compared to normal stroma. Background: Galectin-1 has been found to modulate lymphocyte invasion in inflammation and to be involved in angiogenesis in models, thus prompting examination of its clinical relevance in laryngeal cancer. Patients and Methods: Immunohistochemical processing of tissue sections (n=53) from patients with stage I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was combined with quantitative morphometric analysis. Results: Lectin presence in the tumor and endothelial cells was positively correlated, while a negative relationship to the number of CD45-positive lymphocytes was demonstrated. No association was seen with the extent of neovascularization. The mean optical density (MOD) of lectin-dependent staining in the tumor stroma was significantly, increased compared to normal stroma.
dcterms:title
Adhesion/Growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/Lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas Adhesion/Growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/Lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas
skos:prefLabel
Adhesion/Growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/Lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas Adhesion/Growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/Lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas
skos:notation
RIV/00216208:11110/09:3716!RIV10-MSM-11110___
n4:aktivita
n13:N
n4:aktivity
N
n4:cisloPeriodika
1
n4:dodaniDat
n5:2010
n4:domaciTvurceVysledku
n12:3221105
n4:druhVysledku
n15:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
301977
n4:idVysledku
RIV/00216208:11110/09:3716
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Angiogenesis; galectin-1; laryngeal cancer; lymphocyte; lectin; prognosis; stroma; squamous-cell carcinomas; mammalian lectins; endothelial-cells; ganglioside gm(1); binding-sites; tumor-cells; in-vitro; expression; cancer; growth
n4:klicoveSlovo
n6:endothelial-cells n6:stroma n6:galectin-1 n6:tumor-cells n6:squamous-cell%20carcinomas n6:ganglioside%20gm%281%29 n6:growth n6:mammalian%20lectins n6:expression n6:prognosis n6:cancer n6:lymphocyte n6:in-vitro n6:Angiogenesis n6:laryngeal%20cancer n6:binding-sites n6:lectin
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[2C6B37886D44]
n4:nazevZdroje
Anticancer Research
n4:obor
n17:FF
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
9
n4:rokUplatneniVysledku
n5:2009
n4:svazekPeriodika
29
n4:tvurceVysledku
Ernoux, Perle Smetana, Karel Leroy, Xavier Saussez, Sven Gabius, Hans-Joachim Cludts, Stéphanie Chevalier, Dominique André, Sabine Decaestecker, Christine
n4:wos
000263731100007
s:issn
0250-7005
s:numberOfPages
7
n16:organizacniJednotka
11110