This HTML5 document contains 59 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n6http://localhost/temp/predkladatel/
n15http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n14http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n10http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11110%2F09%3A3714%21RIV10-MSM-11110___/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n13http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F09%3A3714%21RIV10-MSM-11110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The enzymatic activity of matrix metalloproteinase-9 (MMP-9) suggests that its presence in hypopharyngeal and laryngeal squamous cell carcinomas (HSCCs, LSCCs) could have prognostic value. We tested this hypothesis by quantitative morphometric analysis of immunohistochemical staining in histological sections of 73 stage IV HSCCs and 45 LSCCs (30 cases of stage I/II, 15 cases of stage IV). As compared to tumour-free epithelium an increase for the labelling index in LSCCs reached statistical significance (p=0.04). Specimens of Reinke's edema were strongly higher in this parameter compared to tumour-free tissue area (p=0.000001), underscoring an association between the level of MMP-9 expression and inflammation. Focusing on patients' recurrence status we identified thresholds for the labelling index of 10% for HSCCs and 18% for LSCCs, both indicating rapid recurrence and dismal prognosis unless surpassed. The enzymatic activity of matrix metalloproteinase-9 (MMP-9) suggests that its presence in hypopharyngeal and laryngeal squamous cell carcinomas (HSCCs, LSCCs) could have prognostic value. We tested this hypothesis by quantitative morphometric analysis of immunohistochemical staining in histological sections of 73 stage IV HSCCs and 45 LSCCs (30 cases of stage I/II, 15 cases of stage IV). As compared to tumour-free epithelium an increase for the labelling index in LSCCs reached statistical significance (p=0.04). Specimens of Reinke's edema were strongly higher in this parameter compared to tumour-free tissue area (p=0.000001), underscoring an association between the level of MMP-9 expression and inflammation. Focusing on patients' recurrence status we identified thresholds for the labelling index of 10% for HSCCs and 18% for LSCCs, both indicating rapid recurrence and dismal prognosis unless surpassed.
dcterms:title
Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and-7 Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and-7
skos:prefLabel
Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and-7 Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and-7
skos:notation
RIV/00216208:11110/09:3714!RIV10-MSM-11110___
n4:aktivita
n16:N
n4:aktivity
N
n4:cisloPeriodika
2
n4:dodaniDat
n13:2010
n4:domaciTvurceVysledku
n15:3221105
n4:druhVysledku
n17:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
318349
n4:idVysledku
RIV/00216208:11110/09:3714
n4:jazykVysledku
n7:eng
n4:klicovaSlova
collagenase IV; extracellular matrix; gelatinase; lectin; prognosis; relapse-free survival; squamous-cell carcinoma; matrix metalloproteinases; p53-induced gene-1; tumor progression; tissue inhibitor; expression; head; neck; mmp-9; skin
n4:klicoveSlovo
n5:tissue%20inhibitor n5:head n5:expression n5:matrix%20metalloproteinases n5:prognosis n5:p53-induced%20gene-1 n5:relapse-free%20survival n5:skin n5:lectin n5:neck n5:gelatinase n5:tumor%20progression n5:collagenase%20IV n5:squamous-cell%20carcinoma n5:mmp-9 n5:extracellular%20matrix
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[ECA773FB4850]
n4:nazevZdroje
International Journal of Oncology
n4:obor
n9:FF
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
10
n4:rokUplatneniVysledku
n13:2009
n4:svazekPeriodika
34
n4:tvurceVysledku
Gabius, Hans-Joachim Capouillez, Aurelie Saussez, Sven Decaestecker, Christine André, Sabine Mortuaire, Geoffrey Kaltner, Herbert Smetana, Karel Cludts, Stephanie Leroy, Xavier
n4:wos
000262619500017
s:issn
1019-6439
s:numberOfPages
7
n6:organizacniJednotka
11110