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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F14%3A%230000575%21RIV15-MSM-00209805
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.nature.com/ng/journal/v46/n11/full/ng.3105.html
dcterms:description
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
dcterms:title
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
skos:prefLabel
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
skos:notation
RIV/00209805:_____/14:#0000575!RIV15-MSM-00209805
n4:aktivita
n19:P n19:I
n4:aktivity
I, P(ED2.1.00/03.0101)
n4:cisloPeriodika
11
n4:dodaniDat
n7:2015
n4:domaciTvurceVysledku
n5:1030779
n4:druhVysledku
n15:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
18142
n4:idVysledku
RIV/00209805:_____/14:#0000575
n4:jazykVysledku
n16:eng
n4:klicovaSlova
SNP; HLA variants; meta-analysis
n4:klicoveSlovo
n11:SNP n11:meta-analysis n11:HLA%20variants
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[2A69C8309872]
n4:nazevZdroje
Nature genetics
n4:obor
n18:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
122
n4:projekt
n17:ED2.1.00%2F03.0101
n4:rokUplatneniVysledku
n7:2014
n4:svazekPeriodika
46
n4:tvurceVysledku
Cerhan, James R. Foretová, Lenka
s:issn
1061-4036
s:numberOfPages
6
n13:doi
10.1038/ng.3105