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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F14%3A%230000574%21RIV15-MSM-00209805
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0002929714003875
dcterms:description
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 x 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 x 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 x 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DR beta 1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (P-omnibus = 4.20 x 10(-67) to 2.67 x 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 x 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 x 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 x 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 x 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 x 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DR beta 1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (P-omnibus = 4.20 x 10(-67) to 2.67 x 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 x 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 x 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
dcterms:title
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
skos:prefLabel
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
skos:notation
RIV/00209805:_____/14:#0000574!RIV15-MSM-00209805
n4:aktivita
n13:P n13:I
n4:aktivity
I, P(ED2.1.00/03.0101)
n4:cisloPeriodika
4
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n7:1030779
n4:druhVysledku
n15:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
18141
n4:idVysledku
RIV/00209805:_____/14:#0000574
n4:jazykVysledku
n17:eng
n4:klicovaSlova
follicular lyphoma; SNP; HLA variants
n4:klicoveSlovo
n14:SNP n14:follicular%20lyphoma n14:HLA%20variants
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[FBBAC1446D09]
n4:nazevZdroje
The American journal of human genetics
n4:obor
n12:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
112
n4:projekt
n18:ED2.1.00%2F03.0101
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
95
n4:tvurceVysledku
Skibola, C. F. Foretová, Lenka
n4:wos
000342654300011
s:issn
0002-9297
s:numberOfPages
10
n11:doi
10.1016/j.ajhg.2014.09.004