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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F14%3A%230000556%21RIV15-GA0-00209805
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.chom.2014.07.005
dcterms:description
Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations. Among these, the deletion of the UL/b’ domain is associated with loss of virulence. In a screen of UL/b’, we identified pUL135 as a protein responsible for the characteristic cytopathic effect of clinical HCMV strains that also protected from natural killer (NK) and T cell attack. pUL135 interacted directly with abl interactor 1 (ABI1) and ABI2 to recruit the WAVE2 regulatory complex to the plasma membrane, remodel the actin cytoskeleton and dramatically reduce the efficiency of immune synapse (IS) formation. An intimate association between F-actin filaments in target cells and the IS was dispelled by pUL135 expression. Thus, F-actin in target cells plays a critical role in synaptogenesis, and this can be exploited by pathogens to protect against cytotoxic immune effector cells. An independent interaction between pUL135 and talin disrupted cell contacts with the extracellular matrix. Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations. Among these, the deletion of the UL/b’ domain is associated with loss of virulence. In a screen of UL/b’, we identified pUL135 as a protein responsible for the characteristic cytopathic effect of clinical HCMV strains that also protected from natural killer (NK) and T cell attack. pUL135 interacted directly with abl interactor 1 (ABI1) and ABI2 to recruit the WAVE2 regulatory complex to the plasma membrane, remodel the actin cytoskeleton and dramatically reduce the efficiency of immune synapse (IS) formation. An intimate association between F-actin filaments in target cells and the IS was dispelled by pUL135 expression. Thus, F-actin in target cells plays a critical role in synaptogenesis, and this can be exploited by pathogens to protect against cytotoxic immune effector cells. An independent interaction between pUL135 and talin disrupted cell contacts with the extracellular matrix.
dcterms:title
HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells
skos:prefLabel
HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells
skos:notation
RIV/00209805:_____/14:#0000556!RIV15-GA0-00209805
n3:aktivita
n13:P
n3:aktivity
P(ED2.1.00/03.0101), P(GBP206/12/G151)
n3:cisloPeriodika
2
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n8:9637419
n3:druhVysledku
n12:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
18819
n3:idVysledku
RIV/00209805:_____/14:#0000556
n3:jazykVysledku
n19:eng
n3:klicovaSlova
all-trans retinoic acid; caffeic acid; celecoxib; medullobastoma; LOX and COX inhibitors
n3:klicoveSlovo
n6:celecoxib n6:medullobastoma n6:caffeic%20acid n6:all-trans%20retinoic%20acid n6:LOX%20and%20COX%20inhibitors
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[50D4388EEE97]
n3:nazevZdroje
Cell host and microbe
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
19
n3:projekt
n4:ED2.1.00%2F03.0101 n4:GBP206%2F12%2FG151
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
16
n3:tvurceVysledku
Stanton, Richard J. Vojtěšek, Bořivoj
n3:wos
000341144100010
s:issn
1931-3128
s:numberOfPages
14
n16:doi
10.1016/j.chom.2014.07.005