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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F14%3A%230000510%21RIV15-MSM-00209805
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.nature.com/bjc/journal/v110/n8/full/bjc2014105a.html
dcterms:description
Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic response is controversial.We investigated the expression of multiple cancer stem cell markers in human breast cancer samples and cell lines in vitro and in vivo, comparing across and within samples and relating expression with growth and therapeutic response to doxorubicin, docetaxol and radiotherapy. CD24, CD44, ALDH and SOX2 expression, the ability to form mammospheres and side-population cells are variably present in human cancers and cell lines. Each marker identifies a unique rather than common population of cancer cells. In vivo, cells expressing these markers are not specifically localized to the presumptive stem cell niche at the tumour/stroma interface. Repeated therapy does not consistently enrich cells expressing these markers, although ER-negative cells accumulate. Commonly employed methods identify different cancer cell sub-populations with no consistent therapeutic implications, rather than a single population of cells. The relationships of breast cancer stem cells to clinical parameters will require identification of specific markers or panels for the individual cancer. Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic response is controversial.We investigated the expression of multiple cancer stem cell markers in human breast cancer samples and cell lines in vitro and in vivo, comparing across and within samples and relating expression with growth and therapeutic response to doxorubicin, docetaxol and radiotherapy. CD24, CD44, ALDH and SOX2 expression, the ability to form mammospheres and side-population cells are variably present in human cancers and cell lines. Each marker identifies a unique rather than common population of cancer cells. In vivo, cells expressing these markers are not specifically localized to the presumptive stem cell niche at the tumour/stroma interface. Repeated therapy does not consistently enrich cells expressing these markers, although ER-negative cells accumulate. Commonly employed methods identify different cancer cell sub-populations with no consistent therapeutic implications, rather than a single population of cells. The relationships of breast cancer stem cells to clinical parameters will require identification of specific markers or panels for the individual cancer.
dcterms:title
Lack of correlation of stem cell markers in breast cancer stem cells Lack of correlation of stem cell markers in breast cancer stem cells
skos:prefLabel
Lack of correlation of stem cell markers in breast cancer stem cells Lack of correlation of stem cell markers in breast cancer stem cells
skos:notation
RIV/00209805:_____/14:#0000510!RIV15-MSM-00209805
n3:aktivita
n13:P
n3:aktivity
P(ED2.1.00/03.0101)
n3:cisloPeriodika
8
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n4:5713021
n3:druhVysledku
n15:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
25552
n3:idVysledku
RIV/00209805:_____/14:#0000510
n3:jazykVysledku
n11:eng
n3:klicovaSlova
breast cancer stem cells; mammospheres; side-population; therapy resistance
n3:klicoveSlovo
n7:mammospheres n7:therapy%20resistance n7:breast%20cancer%20stem%20cells n7:side-population
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[9AB7C058AF23]
n3:nazevZdroje
British journal of cancer
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n6:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
110
n3:tvurceVysledku
Nenutil, Rudolf
n3:wos
000334587900019
s:issn
0007-0920
s:numberOfPages
9
n16:doi
10.1038/bjc.2014.105