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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000466%21RIV14-MZ0-00209805
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs13277-013-0772-5
dcterms:description
High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy. High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.
dcterms:title
MicroRNAs involved in chemo- and radioresistance of high-grade glioma MicroRNAs involved in chemo- and radioresistance of high-grade glioma
skos:prefLabel
MicroRNAs involved in chemo- and radioresistance of high-grade glioma MicroRNAs involved in chemo- and radioresistance of high-grade glioma
skos:notation
RIV/00209805:_____/13:#0000466!RIV14-MZ0-00209805
n19:predkladatel
n20:ico%3A00209805
n3:aktivita
n13:I n13:P
n3:aktivity
I, P(NT11214)
n3:cisloPeriodika
4
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n7:6231616 Bešše, Andrej n7:5974291
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
88206
n3:idVysledku
RIV/00209805:_____/13:#0000466
n3:jazykVysledku
n17:eng
n3:klicovaSlova
microRNA; glioma; chemoresistance; radioresistance
n3:klicoveSlovo
n15:chemoresistance n15:radioresistance n15:glioma n15:microRNA
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[BF2838E49CD0]
n3:nazevZdroje
Tumor Biology
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n12:NT11214
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
34
n3:tvurceVysledku
Šána, Jiří Bešše, Andrej Slabý, Ondřej
n3:wos
000321912500001
s:issn
1010-4283
s:numberOfPages
20
n18:doi
10.1007/s13277-013-0772-5