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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000442%21RIV14-MZ0-00209805
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-05.pdf
dcterms:description
Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search for novel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal. Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search for novel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal.
dcterms:title
A mini review of organometallic compounds and their anticancer properties A mini review of organometallic compounds and their anticancer properties
skos:prefLabel
A mini review of organometallic compounds and their anticancer properties A mini review of organometallic compounds and their anticancer properties
skos:notation
RIV/00209805:_____/13:#0000442!RIV14-MZ0-00209805
n10:predkladatel
n11:ico%3A00209805
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(ED2.1.00/03.0101)
n3:cisloPeriodika
2
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n13:9637419 n13:2912589 n13:6716539 n13:1330586
n3:druhVysledku
n15:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
58743
n3:idVysledku
RIV/00209805:_____/13:#0000442
n3:jazykVysledku
n19:eng
n3:klicovaSlova
ferrocenes; titanocenes; cytotoxic effect
n3:klicoveSlovo
n4:titanocenes n4:cytotoxic%20effect n4:ferrocenes
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[147BF2DCD630]
n3:nazevZdroje
Folia Mendeliana
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
49
n3:tvurceVysledku
Vyzula, Rostislav Vojtěšek, Bořivoj Koubková, Lucie Hrstka, Roman
s:issn
0085-0748
s:numberOfPages
5