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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000435%21RIV14-MSM-00209805
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://bloodjournal.hematologylibrary.org/content/122/20/3492.full.pdf+html
dcterms:description
Ultraviolet radiation (UVR) exposure has been inversely associated with Hodgkin lymphoma (HL) risk, but only inconsistently, only in a few studies, and without attention to HL heterogeneity. We conducted a pooled analysis of HL risk focusing on type and timing of UVR exposure and on disease subtypes by age, histology, and tumor-cell Epstein-Barr virus (EBV) status. Four case-control studies contributed 1320HL cases and 6381 controls. We estimated lifetime, adulthood, and childhood UVR exposure and history of sunburn and sunlamp use. We used 2-stage estimation with mixed-effects models and weighted pooled effect estimates by inverse marginal variances. We observed statistically significant inverse associations with HL risk for UVR exposures during childhood and adulthood, sunburn history, and sunlamp use, but we found no significant doseresponse relationships. Risks were significant only for EBV-positive HL (pooled odds ratio, 0.56; 95% confidence interval, 0.35 to 0.91 for the highest overall UVR exposure category), with a significant linear trend for overall exposure (P 5 .03). Pooled relative risk estimates were not heterogeneous across studies. Increased UVR exposure may protect against HL, particularly EBV-positive HL. Plausible mechanisms involving UVR induction of regulatory T cells or the cellular DNA damage response suggest opportunities for new prevention targets. Ultraviolet radiation (UVR) exposure has been inversely associated with Hodgkin lymphoma (HL) risk, but only inconsistently, only in a few studies, and without attention to HL heterogeneity. We conducted a pooled analysis of HL risk focusing on type and timing of UVR exposure and on disease subtypes by age, histology, and tumor-cell Epstein-Barr virus (EBV) status. Four case-control studies contributed 1320HL cases and 6381 controls. We estimated lifetime, adulthood, and childhood UVR exposure and history of sunburn and sunlamp use. We used 2-stage estimation with mixed-effects models and weighted pooled effect estimates by inverse marginal variances. We observed statistically significant inverse associations with HL risk for UVR exposures during childhood and adulthood, sunburn history, and sunlamp use, but we found no significant doseresponse relationships. Risks were significant only for EBV-positive HL (pooled odds ratio, 0.56; 95% confidence interval, 0.35 to 0.91 for the highest overall UVR exposure category), with a significant linear trend for overall exposure (P 5 .03). Pooled relative risk estimates were not heterogeneous across studies. Increased UVR exposure may protect against HL, particularly EBV-positive HL. Plausible mechanisms involving UVR induction of regulatory T cells or the cellular DNA damage response suggest opportunities for new prevention targets.
dcterms:title
Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis
skos:prefLabel
Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis
skos:notation
RIV/00209805:_____/13:#0000435!RIV14-MSM-00209805
n10:predkladatel
n11:ico%3A00209805
n3:aktivita
n14:P
n3:aktivity
P(ED2.1.00/03.0101)
n3:cisloPeriodika
20
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n7:1030779
n3:druhVysledku
n15:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
74329
n3:idVysledku
RIV/00209805:_____/13:#0000435
n3:jazykVysledku
n20:eng
n3:klicovaSlova
DNA-damage response; regulatory T-cells; ultraviolet radiation; sun exposure; vitamin D; skin type
n3:klicoveSlovo
n9:vitamin%20D n9:skin%20type n9:ultraviolet%20radiation n9:DNA-damage%20response n9:sun%20exposure n9:regulatory%20T-cells
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9E397A24D8E4]
n3:nazevZdroje
Blood
n3:obor
n19:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
19
n3:projekt
n16:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
122
n3:tvurceVysledku
Foretová, Lenka
n3:wos
000327666500019
s:issn
0006-4971
s:numberOfPages
8
n18:doi
10.1182/blood-2013-04-497586