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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000424%21RIV14-GA0-00209805
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://www.molecular-cancer.com/content/12/1/93
dcterms:description
Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epigenetic mechanisms. Moreover, in the growing tumor, cells are exposed to insufficient nutrient supply, low oxygen availability (hypoxia) and/or reactive oxygen species. These physiological stresses force them to switch into more adaptable and aggressive phenotypes. This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. Furthermore, it describes cross-talk between these factors. Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epigenetic mechanisms. Moreover, in the growing tumor, cells are exposed to insufficient nutrient supply, low oxygen availability (hypoxia) and/or reactive oxygen species. These physiological stresses force them to switch into more adaptable and aggressive phenotypes. This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. Furthermore, it describes cross-talk between these factors.
dcterms:title
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
skos:prefLabel
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
skos:notation
RIV/00209805:_____/13:#0000424!RIV14-GA0-00209805
n16:predkladatel
n17:ico%3A00209805
n3:aktivita
n15:I n15:P
n3:aktivity
I, P(ED2.1.00/03.0101), P(GA13-00956S), P(GBP206/12/G151)
n3:cisloPeriodika
1
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n10:1330586 Obacz, Joanna n10:9637419
n3:druhVysledku
n12:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
67354
n3:idVysledku
RIV/00209805:_____/13:#0000424
n3:jazykVysledku
n13:eng
n3:klicovaSlova
p53; HIF-1; Hypoxia; DNA damage; cancer
n3:klicoveSlovo
n6:cancer n6:p53 n6:Hypoxia n6:HIF-1 n6:DNA%20damage
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0532EAC40410]
n3:nazevZdroje
Molecular Cancer
n3:obor
n18:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n7:GA13-00956S n7:GBP206%2F12%2FG151 n7:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
12
n3:tvurceVysledku
Hrstka, Roman Obacz, Joanna Vojtěšek, Bořivoj
n3:wos
000324067200001
s:issn
1476-4598
s:numberOfPages
10
n19:doi
10.1186/1476-4598-12-93