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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000422%21RIV14-MZ0-00209805
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs13277-013-0777-0
dcterms:description
Clinical behavior of neuroblastoma (NBL) is remarkably heterogeneous, as it ranges from spontaneous regression to aggressive clinical phenotype and death. There is increasing body of evidence demonstrating thatmicroRNAs could be considered the potential biomarkers for clinical applications in NBL. In this report, we focus on molecular characterization of high-risk as well as low-risk and intermediate-risk NBL cases in the context of the microRNA expression profile that is specific for the given risk category of the disease.We investigated a total of 30 NBL patients, out of whom there were 19 patients with low- to intermediate-risk and 11 with high-risk NBLs as defined by the Clinical Oncology Group. We determined the expression profiles of 754 microRNAs (miRNAs), whereas the miRNA expression levels were normalized to RNU44, mean expression levels were calculated, and data were analyzed by use of the microarray biostatistical approaches. We identified the signature of 38 miRNAs differentially expressed between these groups of NBL patients (P<0.05): 17 miRNAs were upregulated and 21 miRNAs were downregulated in the tumors of high-risk NBL patients. We confirm some of the previous observations and we report several new microRNAs associated with aggressive NBL, both being relevant subjects for further translational validation and functional studies. Clinical behavior of neuroblastoma (NBL) is remarkably heterogeneous, as it ranges from spontaneous regression to aggressive clinical phenotype and death. There is increasing body of evidence demonstrating thatmicroRNAs could be considered the potential biomarkers for clinical applications in NBL. In this report, we focus on molecular characterization of high-risk as well as low-risk and intermediate-risk NBL cases in the context of the microRNA expression profile that is specific for the given risk category of the disease.We investigated a total of 30 NBL patients, out of whom there were 19 patients with low- to intermediate-risk and 11 with high-risk NBLs as defined by the Clinical Oncology Group. We determined the expression profiles of 754 microRNAs (miRNAs), whereas the miRNA expression levels were normalized to RNU44, mean expression levels were calculated, and data were analyzed by use of the microarray biostatistical approaches. We identified the signature of 38 miRNAs differentially expressed between these groups of NBL patients (P<0.05): 17 miRNAs were upregulated and 21 miRNAs were downregulated in the tumors of high-risk NBL patients. We confirm some of the previous observations and we report several new microRNAs associated with aggressive NBL, both being relevant subjects for further translational validation and functional studies.
dcterms:title
Extension of microRNA expression pattern associated with high-risk neuroblastoma Extension of microRNA expression pattern associated with high-risk neuroblastoma
skos:prefLabel
Extension of microRNA expression pattern associated with high-risk neuroblastoma Extension of microRNA expression pattern associated with high-risk neuroblastoma
skos:notation
RIV/00209805:_____/13:#0000422!RIV14-MZ0-00209805
n13:predkladatel
n15:ico%3A00209805
n5:aktivita
n17:P n17:I n17:V
n5:aktivity
I, P(ED1.1.00/02.0068), P(ED2.1.00/03.0101), P(NT11214), V
n5:cisloPeriodika
4
n5:dodaniDat
n12:2014
n5:domaciTvurceVysledku
n11:5974291 n11:8285721
n5:druhVysledku
n14:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n9:predkladatel
n5:idSjednocenehoVysledku
74382
n5:idVysledku
RIV/00209805:_____/13:#0000422
n5:jazykVysledku
n6:eng
n5:klicovaSlova
neuroblastoma; risk stratification; microRNA; expression profiling
n5:klicoveSlovo
n16:microRNA n16:risk%20stratification n16:neuroblastoma n16:expression%20profiling
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[2B33CCDBC940]
n5:nazevZdroje
Tumour Biology
n5:obor
n20:FD
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n10:NT11214 n10:ED1.1.00%2F02.0068 n10:ED2.1.00%2F03.0101
n5:rokUplatneniVysledku
n12:2013
n5:svazekPeriodika
34
n5:tvurceVysledku
Slabý, Ondřej Héžová, Renata
n5:wos
000321912500041
s:issn
1010-4283
s:numberOfPages
5
n18:doi
10.1007/s13277-013-0777-0