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Statements

Subject Item
n2:RIV%2F00209805%3A_____%2F13%3A%230000419%21RIV14-GA0-00209805
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://www.mdpi.com/1422-0067/14/8/15681
dcterms:description
The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3´ untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3´ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3´ UTRs may contribute to the development of various disorders in humans. The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3´ untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3´ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3´ UTRs may contribute to the development of various disorders in humans.
dcterms:title
Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders
skos:prefLabel
Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders
skos:notation
RIV/00209805:_____/13:#0000419!RIV14-GA0-00209805
n15:predkladatel
n16:ico%3A00209805
n3:aktivita
n11:I n11:P
n3:aktivity
I, P(ED2.1.00/03.0101), P(GAP301/11/1678), P(GBP206/12/G151)
n3:cisloPeriodika
8
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n4:9637419 n4:1330586 n4:7227078
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
79117
n3:idVysledku
RIV/00209805:_____/13:#0000419
n3:jazykVysledku
n20:eng
n3:klicovaSlova
3´UTR; trinucleotide repeat expansion; polymorphism; mutation; cancer
n3:klicoveSlovo
n13:3%C2%B4UTR n13:mutation n13:trinucleotide%20repeat%20expansion n13:cancer n13:polymorphism
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[F83D4B0C069B]
n3:nazevZdroje
International Journal of Molecular Sciences
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n19:ED2.1.00%2F03.0101 n19:GAP301%2F11%2F1678 n19:GBP206%2F12%2FG151
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Michalová, Eva Vojtěšek, Bořivoj Hrstka, Roman
n3:wos
000328501300025
s:issn
1422-0067
s:numberOfPages
14
n5:doi
10.3390/ijms140815681